Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review

Beckmann, Sven; Dettmer, Matthias S.; Caversaccio, Marco D.; Giger, Roland; Anschütz, Lukas (2020). Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review. Medicina, 56(5) MDPI 10.3390/medicina56050248

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Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Here, we describe an 87-year old female patient with a growing spherical mass in the right external auditory canal. After exclusive endoscopic tumor resection, a ceruminous pleomorphic adenoma was histologically diagnosed. Due to the absence of nuclear pleomorphism, no increased mitotic rate, no perineural invasion and no fusion transcripts of the MYB or MYBL1 gene loci, an adenoid cystic carcinoma could be excluded. The postoperative course was without any evidence of complications. A literature review identified 44 articles with 49 patients that were considered. Hearing loss and ear sensations were the most commonly reported symptoms. Most cases underwent an excision via an endaural or retroauricular approach. Recurrences were described in four patients, three of which had a malignant transformation.
Keywords: Pleomorphic adenoma; ceruminal gland tumor; ceruminous adenoma; endoscopic ear surgery; external auditory canal.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Beckmann, Sven; Dettmer, Matthias; Caversaccio, Marco; Giger, Roland and Anschütz, Lukas Peter

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1648-9144

Publisher:

MDPI

Language:

English

Submitter:

Carmen Heimann

Date Deposited:

15 Dec 2020 15:44

Last Modified:

15 Dec 2020 15:44

Publisher DOI:

10.3390/medicina56050248

PubMed ID:

32443830

BORIS DOI:

10.7892/boris.148422

URI:

https://boris.unibe.ch/id/eprint/148422

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