Mosher, Kira I.; Andres, Robert H.; Fukuhara, Takeshi; Bieri, Gregor; Hasegawa-Moriyama, Maiko; He, Yingbo; Guzman, Raphael; Wyss-Coray, Tony (2012). Neural progenitor cells regulate microglia functions and activity. Nature neuroscience, 15(11), pp. 1485-1487. New York, N.Y.: Nature America 10.1038/nn.3233
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Neural Progenitor Cells Regulate Microglia Functions and Activity States.pdf - Accepted Version Available under License Publisher holds Copyright. Download (3MB) | Preview |
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Andres, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1097-6256 |
Publisher: |
Nature America |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1038/nn.3233 |
PubMed ID: |
23086334 |
Web of Science ID: |
000310424900007 |
BORIS DOI: |
10.7892/boris.14843 |
URI: |
https://boris.unibe.ch/id/eprint/14843 (FactScience: 221977) |
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