Neural progenitor cells regulate microglia functions and activity

Mosher, Kira I.; Andres, Robert H.; Fukuhara, Takeshi; Bieri, Gregor; Hasegawa-Moriyama, Maiko; He, Yingbo; Guzman, Raphael; Wyss-Coray, Tony (2012). Neural progenitor cells regulate microglia functions and activity. Nature neuroscience, 15(11), pp. 1485-1487. New York, N.Y.: Nature America 10.1038/nn.3233

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We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Andres, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-6256

Publisher:

Nature America

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:37

Last Modified:

10 Dec 2014 10:58

Publisher DOI:

10.1038/nn.3233

PubMed ID:

23086334

Web of Science ID:

000310424900007

BORIS DOI:

10.7892/boris.14843

URI:

https://boris.unibe.ch/id/eprint/14843 (FactScience: 221977)

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