Hypersensitivity and oral tolerance in the absence of a secretory immune system

Karlsson, M R; Johansen, F-E; Kahu, H; Macpherson, A; Brandtzaeg, P (2010). Hypersensitivity and oral tolerance in the absence of a secretory immune system. Allergy, 65(5), pp. 561-70. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2009.02225.x

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Mucosal immunity protects the epithelial barrier by immune exclusion of foreign antigens and by anti-inflammatory tolerance mechanisms, but there is a continuing debate about the role of secretory immunoglobulins (SIgs), particularly SIgA, in the protection against allergy and other inflammatory diseases. Lack of secretory antibodies may cause immune dysfunction and affect mucosally induced (oral) tolerance against food antigens.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Macpherson, Andrew

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1111/j.1398-9995.2009.02225.x

PubMed ID:

19886928

Web of Science ID:

000276244900003

URI:

https://boris.unibe.ch/id/eprint/1485 (FactScience: 203165)

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