Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities.

Azparren-Angulo, Maria; Royo, Felix; Gonzalez, Esperanza; Liebana, Marc; Brotons, Bruno; Berganza, Jesús; Goñi-de-Cerio, Felipe; Manicardi, Nicoló; Abad-Jordà, Laia; Gracia Sancho, Jorge; Falcon-Perez, Juan M (2021). Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities. Pharmacology & therapeutics, 218, p. 107683. Elsevier 10.1016/j.pharmthera.2020.107683

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Since the first descriptions of hepatocyte-released exosome-like vesicles in 2008, the number of publications describing Extracellular Vesicles (EVs) released by liver cells in the context of hepatic physiology and pathology has grown exponentially. This growing interest highlights both the importance that cell-to-cell communication has in the organization of multicellular organisms from a physiological point of view, as well as the opportunity that these circulating organelles offer in diagnostics and therapeutics. In the present review, we summarize systematically and comprehensively the myriad of works that appeared in the last decade and lighted the discussion about the best opportunities for using EVs in liver disease therapeutics.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Gracia Sancho, Jorge Sergio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0163-7258

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

09 Dec 2020 18:28

Last Modified:

15 Jan 2021 01:33

Publisher DOI:

10.1016/j.pharmthera.2020.107683

PubMed ID:

32961265

Uncontrolled Keywords:

Diagnostics EVs Exosomes Liver disease Microvesicles Therapeutics

BORIS DOI:

10.7892/boris.148515

URI:

https://boris.unibe.ch/id/eprint/148515

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