Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma.

Thorball, Christian W; Oudot-Mellakh, Tiphaine; Ehsan, Nava; Hammer, Christian; Santoni, Federico A; Niay, Jonathan; Costagliola, Dominique; Goujard, Cécile; Meyer, Laurence; Wang, Sophia S; Hussain, Shehnaz K; Theodorou, Ioannis; Cavassini, Matthias; Rauch, Andri; Battegay, Manuel; Hoffmann, Matthias; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F; Mohammadi, Pejman; ... (2020). Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma. (In Press). Haematologica - the hematology journal Ferrata-Storti Foundation 10.3324/haematol.2020.247023

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Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the general population. To identify potential genetic risk loci, we performed case-control genome-wide association studies and a meta-analysis across three cohorts of HIV+ patients of European ancestry, including a total of 278 cases and 1924 matched controls. We observed a significant association with NHL susceptibility in the C-X-C motif chemokine ligand 12 (CXCL12) region on chromosome 10. A fine mapping analysis identified rs7919208 as the most likely causal variant (P = 4.77e-11), with the G>A polymorphism creating a new transcription factor binding site for BATF and JUND. These results suggest a modulatory role of CXCL12 regulation in the increased susceptibility to NHL observed in the HIV-infected population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Rauch, Andri

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0390-6078

Publisher:

Ferrata-Storti Foundation

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

18 Dec 2020 11:00

Last Modified:

18 Dec 2020 11:00

Publisher DOI:

10.3324/haematol.2020.247023

PubMed ID:

32675224

Uncontrolled Keywords:

Aggressive Non-Hodgkin's Lymphoma Genetics HIV Infectious Disorders

BORIS DOI:

10.7892/boris.148541

URI:

https://boris.unibe.ch/id/eprint/148541

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