Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.

Cudalbu, Cristina; Behar, Kevin L; Bhattacharyya, Pallab K; Bogner, Wolfgang; Borbath, Tamas; de Graaf, Robin A; Gruetter, Rolf; Henning, Anke; Juchem, Christoph; Kreis, Roland; Lee, Phil; Lei, Hongxia; Marjańska, Małgorzata; Mekle, Ralf; Murali-Manohar, Saipavitra; Považan, Michal; Rackayová, Veronika; Simicic, Dunja; Slotboom, Johannes; Soher, Brian J; ... (2021). Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. NMR in biomedicine, 34(5), e4393. Wiley 10.1002/nbm.4393

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Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

UniBE Contributor:

Kreis, Roland and Slotboom, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1099-1492

Publisher:

Wiley

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

16 Dec 2020 15:35

Last Modified:

21 Apr 2021 01:31

Publisher DOI:

10.1002/nbm.4393

PubMed ID:

33236818

Uncontrolled Keywords:

brain macromolecules fitting metabolite quantification mobile lipids parameterization proton magnetic resonance spectroscopy quantification spectral analysis

BORIS DOI:

10.7892/boris.148627

URI:

https://boris.unibe.ch/id/eprint/148627

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