Lai, Stefano; Lingström, Peter; Cagetti, Maria Grazia; Cocco, Fabio; Meloni, Gianfranco; Arrica, Maria Antonietta; Campus, Guglielmo (2021). Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial. Clinical oral investigations, 25(1), pp. 115-123. Springer-Verlag 10.1007/s00784-020-03342-0
|
Text
Lai_et_al._Clin_Oral_Investig_2020.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (530kB) | Preview |
OBJECTIVE
The short-term effect (60 days) of Lactobacillus brevis CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated.
MATERIAL AND METHODS
Eight diabetics (4-14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t0), 30 days (t1), 60 days (t2) and in the follow-up period (90 days from baseline, t3). Gingival status was assessed at t0, t2 and t3. Two-way ANOVA assessed differences between groups.
RESULTS
In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t2) and to 2.06 ± 0.56 (t3), while in the placebo group, the scores were 3.09 ± 0.8 (t0), 2.82 ± 0.47 (t2) and 3.11 ± 0.43 (t3) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t3 (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t2 in the probiotic group (25.6%, 95% CI 21.5-32.7 vs 29.5%, 95% CI 25.2-34.9, p = 0.02).
CONCLUSIONS
Lactobacillus brevis CD2 has shown to improve caries-related risk factors and gingival health in diabetic children.
CLINICAL RELEVANCE
Lactobacillus brevis CD2 might contribute to improved oral health in type 1 diabetic children.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry |
UniBE Contributor: |
Campus, Guglielmo Giuseppe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Daniela Zesiger |
Date Deposited: |
22 Dec 2020 10:34 |
Last Modified: |
05 Dec 2022 15:42 |
Publisher DOI: |
10.1007/s00784-020-03342-0 |
PubMed ID: |
33083852 |
Uncontrolled Keywords: |
Caries Children Lactobacillus brevis CD2 Plaque pH Probiotic Salivary mutans streptococci |
BORIS DOI: |
10.7892/boris.148655 |
URI: |
https://boris.unibe.ch/id/eprint/148655 |
Actions (login required)
 |
Edit item |