Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial.

Lai, Stefano; Lingström, Peter; Cagetti, Maria Grazia; Cocco, Fabio; Meloni, Gianfranco; Arrica, Maria Antonietta; Campus, Guglielmo (2021). Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial. Clinical oral investigations, 25(1), pp. 115-123. Springer-Verlag 10.1007/s00784-020-03342-0

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OBJECTIVE

The short-term effect (60 days) of Lactobacillus brevis CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated.

MATERIAL AND METHODS

Eight diabetics (4-14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t0), 30 days (t1), 60 days (t2) and in the follow-up period (90 days from baseline, t3). Gingival status was assessed at t0, t2 and t3. Two-way ANOVA assessed differences between groups.

RESULTS

In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t2) and to 2.06 ± 0.56 (t3), while in the placebo group, the scores were 3.09 ± 0.8 (t0), 2.82 ± 0.47 (t2) and 3.11 ± 0.43 (t3) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t3 (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t2 in the probiotic group (25.6%, 95% CI 21.5-32.7 vs 29.5%, 95% CI 25.2-34.9, p = 0.02).

CONCLUSIONS

Lactobacillus brevis CD2 has shown to improve caries-related risk factors and gingival health in diabetic children.

CLINICAL RELEVANCE

Lactobacillus brevis CD2 might contribute to improved oral health in type 1 diabetic children.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Campus, Guglielmo Giuseppe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-6981

Publisher:

Springer-Verlag

Language:

English

Submitter:

Daniela Zesiger

Date Deposited:

22 Dec 2020 10:34

Last Modified:

23 Feb 2021 19:49

Publisher DOI:

10.1007/s00784-020-03342-0

PubMed ID:

33083852

Uncontrolled Keywords:

Caries Children Lactobacillus brevis CD2 Plaque pH Probiotic Salivary mutans streptococci

BORIS DOI:

10.7892/boris.148655

URI:

https://boris.unibe.ch/id/eprint/148655

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