Citrullination in periodontium is associated with Porphyromonas gingivalis.

Maldonado, Alejandra; Pirracchio, Luca; Imber, Jean-Claude; Bürgin, Walter; Möller, Burkhard; Sculean, Anton; Eick, Sigrun (2020). Citrullination in periodontium is associated with Porphyromonas gingivalis. Archives of oral biology, 114, p. 104695. Elsevier Science 10.1016/j.archoralbio.2020.104695

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To analyse the citrulline level in the periodontium in association with the presence of or antibody levels against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.


Gingival crevicular fluid (GCF), subgingival biofilm and blood serum were sampled from 98 subjects (26 with RA, 72 without RA (NoRA)). GCF was analyzed for the level of citrulline, for interleukin (IL)-1β, IL-17, IL-10 and monocyte-chemoattractant protein (MCP)-1. Microorganisms were identified in subgingival biofilms. Antibodies againstP. gingivalis, and Aggregatibacter actinomycetemcomitans were quantified in serum.


GCF citrulline level was the lowest (by trend) in NoRA group without periodontitis. In NoRA, but not in RA an association between GCF citrulline level and P. gingivalis antibody levels was found and the GCF citrulline levels were higher in P. gingivalis positive samples. Any association of A. actinomycetemcomitans with GCF citrulline level did not exist. A model of univariate variance analysis (p = 0.001) showed a dependence of GCF citrulline level from the number of sites with PD (probing depth) ≥5 mm (p = 0.003) and the GCF MCP-1/CCL2 level (p = 0.019). Compared with NoRA in RA the number of teeth was lower, the number of sites with PD ≥ 5 mm was less, GCF levels of interleukin-17 and MCP-1/CCL2 were higher and those of IL-10 lower. Yeasts were only cultured in 15 RA patients (p < 0.001).


Citrullination in periodontium might be associated with P. gingivalis supporting the potential role as a trigger in the development of RA. Pathogenesis of periodontal disease in RA patients seems to differ from that in NoRA and should be investigated further.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research

UniBE Contributor:

Maldonado, Alejandra, Pirracchio, Luca, Imber, Jean-Claude, Möller, Burkhard, Sculean, Anton, Eick, Sigrun


600 Technology > 610 Medicine & health




Elsevier Science




Doris Burri

Date Deposited:

08 Dec 2020 14:31

Last Modified:

05 Dec 2022 15:42

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Biomarker Citrulline Periodontal disease Periodontopathogen Rheumatoid arthritis




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