Cosgarea, Raluca; Pollmann, Robert; Sharif, Jusra; Schmidt, Thomas; Stein, Ronja; Bodea, Aura; Auschill, Thorsten; Sculean, Anton; Eming, Rüdiger; Greene, Brandon; Hertl, Michael; Arweiler, Nicole (2020). Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study. Scientific reports, 10(1), p. 1667. Springer Nature 10.1038/s41598-020-58548-9
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Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. Twenty patients with OLP were treated with PDT in a prospective case-controlled pilot-study. PDT was performed on the most extensive oral lesion in 4 sessions (day 1, 3, 7, 14). Peripheral blood and lesional T cells were analysed before (day 1) and after PDT treatment (day 28). PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. The clinical improvement was accompanied by a significant decrease of the relative number of CD4+ and CD8+ T cells in mucosal OLP-lesions. Furthermore, CXCL10 plasma levels were decreased and the number of activated peripheral CD4 + CD137+ and CD8 + CD137+ T cells and IL-17-secreting T cells was diminished. PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Doris Burri |
Date Deposited: |
15 Dec 2020 16:37 |
Last Modified: |
05 Dec 2022 15:42 |
Publisher DOI: |
10.1038/s41598-020-58548-9 |
PubMed ID: |
32015380 |
BORIS DOI: |
10.7892/boris.148682 |
URI: |
https://boris.unibe.ch/id/eprint/148682 |
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