Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study.

Cosgarea, Raluca; Pollmann, Robert; Sharif, Jusra; Schmidt, Thomas; Stein, Ronja; Bodea, Aura; Auschill, Thorsten; Sculean, Anton; Eming, Rüdiger; Greene, Brandon; Hertl, Michael; Arweiler, Nicole (2020). Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study. Scientific reports, 10(1), p. 1667. Springer Nature 10.1038/s41598-020-58548-9

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Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. Twenty patients with OLP were treated with PDT in a prospective case-controlled pilot-study. PDT was performed on the most extensive oral lesion in 4 sessions (day 1, 3, 7, 14). Peripheral blood and lesional T cells were analysed before (day 1) and after PDT treatment (day 28). PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. The clinical improvement was accompanied by a significant decrease of the relative number of CD4+ and CD8+ T cells in mucosal OLP-lesions. Furthermore, CXCL10 plasma levels were decreased and the number of activated peripheral CD4 + CD137+ and CD8 + CD137+ T cells and IL-17-secreting T cells was diminished. PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Sculean, Anton


600 Technology > 610 Medicine & health




Springer Nature




Doris Burri

Date Deposited:

15 Dec 2020 16:37

Last Modified:

23 Feb 2021 20:58

Publisher DOI:


PubMed ID:





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