Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox.

Jeyakumar, Jenaniy; Sculean, Anton; Eick, Sigrun (2020). Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox. Oral health & preventive dentistry, 18(1), pp. 981-990. Quintessenz Verlags-GmbH 10.3290/j.ohpd.a45437

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PURPOSE

To analyze in vitro new formulations with Citrox and chlorhexidine digluconate (CHX) regarding their antibacterial activity against planktonic bacteria and their potential to inhibit biofilm formation or to act on existing biofilms.

MATERIALS AND METHODS

Five oral health care products with 0.05%-0.5% CHX formulations (four rinses and one gel) were compared with Citrox preparations and additive-free CHX solutions. The minimal inhibitory concentrations (MIC) were determined against 13 oral bacteria associated with caries or periodontitis. Further, the activity on retarding biofilm formation and on existing biofilms was analyzed; both a 'cariogenic' (5 species) and a 'periodontal' (12 species) biofilm were included.

RESULTS

The MIC values did not differ between the CHX mouthrinse/gel formulations and the respective additive-free CHX solutions. Citrox was active against selected periodontopathogens (e.g. Porphyromonas gingivalis). The CHX formulations more effectively retarded biofilm formation than did solutions with the same concentration of CHX but without additives. The anti-biofilm activities depended on the CHX concentration in the formulations. Both CHX solutions and formulations (rinse and gel) were only slightly active on an already formed biofilm. Citrox did not exert any anti-biofilm effect.

CONCLUSION

The present in vitro data support the anti-biofilm activity of the novel CHX, Citrox, poly-L-lysine and xylitol oral health-care formulations. Further studies are warranted to confirm the present findings in various clinical settings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Sculean, Anton and Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1602-1622

Publisher:

Quintessenz Verlags-GmbH

Language:

English

Submitter:

Doris Burri

Date Deposited:

01 Dec 2020 10:36

Last Modified:

01 Dec 2020 10:36

Publisher DOI:

10.3290/j.ohpd.a45437

PubMed ID:

33215489

Uncontrolled Keywords:

biofilm caries chlorhexidine digluconate mouthrinse periodontitis

BORIS DOI:

10.7892/boris.148683

URI:

https://boris.unibe.ch/id/eprint/148683

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