Transgingival photodynamic therapy (tg-aPDT) adjunctive to subgingival mechanical instrumentation in supportive periodontal therapy. A randomized controlled clinical study.

Schär, Dorothee; Ramseier, Christoph A.; Eick, Sigrun; Mettraux, Gérald; Salvi, Giovanni E.; Sculean, Anton (2020). Transgingival photodynamic therapy (tg-aPDT) adjunctive to subgingival mechanical instrumentation in supportive periodontal therapy. A randomized controlled clinical study. Photodiagnosis and photodynamic therapy, 32, p. 101971. Elsevier 10.1016/j.pdpdt.2020.101971

[img] Text
1-s2.0-S1572100020303252-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

BACKGROUND

Recent data from preclinical studies and case series suggest that transgingival irradiation with diode lasers may represent a novel modality for antimicrobial photodynamic therapy (aPDT). However, at present, there is lack of data from controlled clinical studies on the use of transgingival antimicrobial photodynamic therapy (tg-aPDT) in the treatment of periodontitis.

OBJECTIVE

To evaluate the clinical effects of tg-aPDT used in conjunction with nonsurgical mechanical instrumentation during supportive periodontal therapy (SPT).

MATERIALS AND METHODS

Forty stage II and III periodontitis patients enrolled in SPT were randomly assigned to two groups of equal size. At baseline, study sites had to show sites with pocket probing depth (PPD) of ≥ 5 mm and Bleeding on Probing (BOP). Full mouth and site-specific Plaque-Index scores (PI), BOP, PPD, and Clinical Attachment Level (CAL) were recorded at baseline (BL), three months (3 M), and 6 months (6 M), respectively. The primary outcome variable was the change in the number of sites with BOP. Treatment was performed under local anaesthesia after random allocation to one of the following groups 1) Subgingival scaling and root planing (SRP) + tg-aPDT (test) or 2) SRP alone (control).

RESULTS

Thirty-nine patients completed the study. Full mouth PI and BOP improved over six month, however without statistically significant difference between the groups. At 6 M, BOP-levels were statistically significantly lower in test sites (25.0%) compared to the control sites (65.0%), (p < 0.025). PPD improved in both groups with comparable mean values at 3 M (PPD test: 5.21 ± 0.92 mm; PPD control: 4.45 ± 1.36 mm) and 6 M (PPD test: 5.11 ± 1.10 mm; PPD control: 4.35 ± 1.14 mm). Additionally, CAL slightly improved in both groups with comparable mean values at 3 M (CAL test: 6.79 ± 1.72 mm; CAL control: 5.30 ± 2.43 mm) and 6 M (CAL test: 6.26 ± 1.70 mm; CAL control: 5.50 ± 2.33 mm).

CONCLUSIONS

Within its limits, the present results appear to indicate that the use of tg-aPDT adjunctive to SRP may represent a new modality for controlling inflammation and further bleeding in residual periodontal pockets.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Schär, Dorothee; Ramseier, Christoph Andreas; Eick, Sigrun; Mettraux, Gérald; Salvi, Giovanni Edoardo and Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-1597

Publisher:

Elsevier

Language:

English

Submitter:

Doris Burri

Date Deposited:

29 Dec 2020 11:34

Last Modified:

03 Jan 2021 02:52

Publisher DOI:

10.1016/j.pdpdt.2020.101971

PubMed ID:

32835882

Uncontrolled Keywords:

Transgingival antibacterial photodynamic therapy non-surgical periodontal treatment scaling and root planing supportive periodontal therapy tg-aPDT

BORIS DOI:

10.48350/148693

URI:

https://boris.unibe.ch/id/eprint/148693

Actions (login required)

Edit item Edit item
Provide Feedback