Neuro-Immune Circuits Regulate Immune Responses in Tissues and Organ Homeostasis.

Jakob, Manuel O.; Murugan, Shaira; Klose, Christoph S. N. (2020). Neuro-Immune Circuits Regulate Immune Responses in Tissues and Organ Homeostasis. Frontiers in immunology, 11(308), p. 308. Frontiers Research Foundation 10.3389/fimmu.2020.00308

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The dense innervation of the gastro-intestinal tract with neuronal networks, which are in close proximity to immune cells, implies a pivotal role of neurons in modulating immune functions. Neurons have the ability to directly sense danger signals, adapt immune effector functions and integrate these signals to maintain tissue integrity and host defense strategies. The expression pattern of a large set of immune cells in the intestine characterized by receptors for neurotransmitters and neuropeptides suggest a tight neuronal hierarchical control of immune functions in order to systemically control immune reactions. Compelling evidence implies that targeting neuro-immune interactions is a promising strategy to dampen immune responses in autoimmune diseases such as inflammatory bowel diseases or rheumatoid arthritis. In fact, electric stimulation of vagal fibers has been shown to be an extremely effective treatment strategy against overwhelming immune reactions, even after exhausted conventional treatment strategies. Such findings argue that the nervous system is underestimated coordinator of immune reactions and underline the importance of neuro-immune crosstalk for body homeostasis. Herein, we review neuro-immune interactions with a special focus on disease pathogenesis throughout the gastro-intestinal tract.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Jakob, Manuel and Murugan, Shaira

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

18 Dec 2020 18:23

Last Modified:

25 May 2021 16:01

Publisher DOI:

10.3389/fimmu.2020.00308

PubMed ID:

32265899

Uncontrolled Keywords:

autonomous nervous system chronic inflammatory diseases enteric nervous system (ENS) neuro-immune interactions tissue homeostasis

BORIS DOI:

10.7892/boris.148698

URI:

https://boris.unibe.ch/id/eprint/148698

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