Effects of Dentifrices Differing in Fluoride Content on Remineralization Characteristics of Dentin in vitro.

Wierichs, Richard J; Rupp, Katharina; Meyer-Lueckel, Hendrik; Apel, Christian; Esteves-Oliveira, Marcella (2020). Effects of Dentifrices Differing in Fluoride Content on Remineralization Characteristics of Dentin in vitro. Caries research, 54(1), pp. 75-86. Karger 10.1159/000504165

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OBJECTIVES

The aim of this study was to compare the caries preventive effect of highly fluoridated dentifrices and gels on sound dentin as well as on artificial dentin caries-like lesions.

METHODS

Bovine dentin specimens (n = 240), with 2 different surfaces each (1 sound surface [sound treatment (ST)] and one caries lesion [demineralized treatment (DT)]), were prepared and randomly allocated to one highly (6 × 120 min demineralization/day [H]) and one lowly cariogenic (6 × 60 min demineralization/day [L]) pH-cycling model. Treatments during pH-cycling (28 days) were: brushing 2×/day with: 0 ppm F [H0/L0], 1,450 ppm F [H1,450/L1,450], 2,800 ppm F [H2,800/L2,800], 5,000 ppm F [H5,000/L5,000], 5,000 ppm F plus TCP [H5,000+TCP/L5,000+TCP], and 12,500 ppm F [H12,500/L12,500] containing dentifrices/gels. Dentifrice/gel slurries were prepared with deionized water (1:2 wt/wt). Differences in integrated mineral loss (∆∆Z) and ∆ lesion depth were calculated between values before and after pH-cycling using transversal microradiography.

RESULTS

The correlation between ΔΔZDT and F- was strong for the highly (rH = 0.691; p < 0.001) and moderate (rL = 0.500; p < 0.001) for the lowly cariogenic model, indicating a fluoride dose-response for both. Significant differences for ΔΔZDT and ΔΔZST could be found between H0, H1,450, H5,000, and H12,500 as well as L0, L5,000, and L125,000 (p ≤ 0.046; analysis of covariance [ANCOVA]). Except for 0 ppm F-, no significant difference in ΔΔZST and ΔΔZDT could be found between the highly and lowly cariogenic model (p ≥ 0.056; ANCOVA).

CONCLUSION

For both pH-cycling conditions a dose-response for fluoride could be revealed. For elderly people with exposed root surfaces, the use of gels containing 12,500 ppm F instead of regularly (1,450 ppm F) or highly (5,000 ppm F) fluoridated dentifrices should be further investigated, as it offered higher caries-preventive effects in vitro.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Meyer-Lückel, Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0008-6568

Publisher:

Karger

Language:

English

Submitter:

Daniela Zesiger

Date Deposited:

23 Dec 2020 15:07

Last Modified:

05 Dec 2022 15:42

Publisher DOI:

10.1159/000504165

PubMed ID:

31775152

Uncontrolled Keywords:

Dentin caries Fluoride Noncavitated caries lesions Remineralization Toothpastes pH-cycling

BORIS DOI:

10.48350/148705

URI:

https://boris.unibe.ch/id/eprint/148705

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