Tooth survival and clinical outcomes up to 26 years after guided tissue regeneration therapy in deep intra-bony defects: Follow-up investigation of three randomized clinical trials.

Cieplik, Fabian; Ihlenfeld, Insa; Hiller, Karl-Anton; Pummer, Andreas; Schmalz, Gottfried; Buchalla, Wolfgang; Christgau, Michael (2020). Tooth survival and clinical outcomes up to 26 years after guided tissue regeneration therapy in deep intra-bony defects: Follow-up investigation of three randomized clinical trials. Journal of clinical periodontology, 47(7), pp. 863-874. Wiley 10.1111/jcpe.13302

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AIM

To investigate tooth survival and clinical long-term outcomes up to 26 years following guided tissue regeneration (GTR) therapy in deep intra-bony defects.

METHODS

Patients from three prospective clinical split-mouth studies, which investigated the outcomes of GTR therapy, were re-evaluated 21-26 years after surgery independent of the membrane type used, and tooth survival was assessed according to several site-specific and patient-related factors.

RESULTS

About 50 patients contributing 102 defects were available for this long-term follow-up. After up to 26 years (median 23.3 years), 52.9% of the teeth were still in situ. The median survival of the extracted teeth was 13.8 years. Patients with diabetes mellitus and/or smoking history lost significantly more teeth in the long term. Compared to the 1-year situation, there was no new median CAL loss after up to 26 years in the teeth which were still in situ.

CONCLUSIONS

Within the limitations of this study, our data show that more than 50% of the initially seriously diseased teeth were still in situ up to 26 years following GTR therapy despite an overall limited adherence to SPT. In the majority of these teeth, the CAL gain 1 year after GTR could be maintained over this long period.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Schmalz, Gottfried Hans

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-6979

Publisher:

Wiley

Language:

English

Submitter:

Doris Burri

Date Deposited:

22 Dec 2020 08:23

Last Modified:

22 Dec 2020 08:23

Publisher DOI:

10.1111/jcpe.13302

PubMed ID:

32390170

Uncontrolled Keywords:

guided tissue regeneration intra-bony defects long-term results periodontal surgery

BORIS DOI:

10.7892/boris.148775

URI:

https://boris.unibe.ch/id/eprint/148775

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