Past, present and future EEG in the clinical workup of dementias.

Koenig, Thomas; Smailovic, Una; Jelic, Vesna (2020). Past, present and future EEG in the clinical workup of dementias. Psychiatry research: Neuroimaging, 306(111182), p. 111182. Elsevier 10.1016/j.pscychresns.2020.111182

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Electroencephalography (EEG), as non-invasive, global measure of neuronal activity, is a prime candidate functional marker of synapse dysfunction and loss in dementias. Nevertheless, EEG currently has no established role in the clinical workup of individual patients. This opinion paper presents our critical view on why EEG has so far failed to keep its promise, and where we believe EEG will be clinically useful for patients threatened with cognitive decline in the future. Individual EEGs are an integral outcome of many causally intermixing upstream factors contributing to dementia. Therefore, EEG cannot become a clinically useful "simple" stand-alone biomarker of some pathognomic accumulations of specific brain proteins, but rather offer unique opportunities for more comprehensive and richly faceted insights into the functional status of brain systems. EEG may thus remain an essential window into the brain when it comes to the at-risk and presymptomatic phases of dementias, where it can be uniquely informative about concepts such as burdens of plasticity and repair, cognitive reserve, and sleep. Jointly with rapid gains in usability, portability, machine learning, closed loop systems, and understanding of the role of EEG-based sleep stages for memory and brain repair, EEG may come to keep its initial promise after all.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

23 Dec 2020 14:19

Last Modified:

27 Dec 2020 02:50

Publisher DOI:

10.1016/j.pscychresns.2020.111182

PubMed ID:

32921526

Uncontrolled Keywords:

Biomarker Brain vitality Cognitive reserve Connectivity Disease modification Inverse problem Levy body dementia Microstates Plasticity Prevention Proteinopathies Sleep Synaptic dysfunction Synchronization

BORIS DOI:

10.48350/148860

URI:

https://boris.unibe.ch/id/eprint/148860

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