Early life maltreatment and resting-state heart rate variability: A systematic review and meta-analysis

Sigrist, Christine; Mürner-Lavanchy, Ines; Peschel, Stephanie K.V.; Schmidt, Stefanie Julia; Kaess, Michael; Koenig, Julian (2021). Early life maltreatment and resting-state heart rate variability: A systematic review and meta-analysis. Neuroscience & biobehavioral reviews, 120, pp. 307-334. Elsevier 10.1016/j.neubiorev.2020.10.026

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Recent focus on the consequences of early life adversity (ELA) in neurobiological research led to a variety of findings suggesting alterations in several physiological systems, such as the cardiovascular system. In this systematic review and meta-analysis, we focused on the relationship between early life maltreatment (ELM), one form of ELA, and resting vagal activity indexed by resting-state heart rate variability (HRV). A systematic search of the literature yielded 1'264 hits, of which 32 studies reporting data for group comparisons or correlations were included. By quantitative synthesis of existing studies using random-effect models, we found no evidence for a relationship between ELM exposure and resting vagal activity in principal. Conducting meta-regression analyses, however, we found the relationship between ELM and resting vagal activity to significantly vary as a function of both age and the presence of psychopathology. In light of the current multitude of vastly unclear pathways linking ELM to the onset of disease, we emphasize the need for further research and outline several aspects to consider in future studies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Sigrist, Christine; Mürner-Lavanchy, Ines; Schmidt, Stefanie Julia; Kaess, Michael and Koenig, Julian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0149-7634

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Michel

Date Deposited:

24 Dec 2020 09:04

Last Modified:

02 Feb 2021 01:33

Publisher DOI:

10.1016/j.neubiorev.2020.10.026

PubMed ID:

33171141

BORIS DOI:

10.7892/boris.148920

URI:

https://boris.unibe.ch/id/eprint/148920

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