Case Report: Diagnostic Challenges in the Detection of a Mixed Plasmodium vivax/ovale Infection in a Non-Endemic Setting.

Nguyen, Ha Thu Trang; Romano, Fabrizio; Wampfler, Rahel; Mühlethaler, Konrad; Tannich, Egbert; Oberli, Alexander (2020). Case Report: Diagnostic Challenges in the Detection of a Mixed Plasmodium vivax/ovale Infection in a Non-Endemic Setting. The American Journal of Tropical Medicine and Hygiene, 103(3), pp. 1085-1087. American Society of Tropical Medicine and Hygiene 10.4269/ajtmh.20-0079

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In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the case of an 8-year-old girl migrating with her family from Afghanistan with a two-species mixed infection with Plasmodium vivax and Plasmodium ovale. This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation procedure to prevent underestimation of mixed-species infections. To our knowledge, this is the first case report of a two-species mixed infection comprising both P. vivax and P. ovale confirmed by LM and different real-time polymerase chain reaction (PCR) approaches.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Notfallzentrum für Kinder und Jugendliche
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Infection Serology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Nguyen, Ha Thu Trang; Romano, Fabrizio; Mühlethaler, Konrad and Oberli, Alexander Oliver

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0002-9637

Publisher:

American Society of Tropical Medicine and Hygiene

Language:

English

Submitter:

Konrad Mühlethaler-Ruckstuhl

Date Deposited:

23 Dec 2020 14:47

Last Modified:

22 Jul 2021 11:02

Publisher DOI:

10.4269/ajtmh.20-0079

PubMed ID:

32314695

BORIS DOI:

10.48350/148961

URI:

https://boris.unibe.ch/id/eprint/148961

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