Gender differences in adolescent sleep neurophysiology: a high-density sleep EEG study

Markovic, Andjela; Kaess, Michael; Tarokh, Leila (2020). Gender differences in adolescent sleep neurophysiology: a high-density sleep EEG study. Scientific Reports, 10(1), p. 15935. Nature Publishing Group 10.1038/s41598-020-72802-0

[img]
Preview
Text
s41598-020-72802-0.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (2MB) | Preview

During adolescence, differences between males and females in physiology, behavior and risk for psychopathology are accentuated. The goal of the current study was to examine gender differences in sleep neurophysiology using high-density sleep EEG in early adolescence. We examined gender differences in sleep EEG power and coherence across frequency bands for both NREM and REM sleep in a sample of 61 adolescents (31 girls and 30 boys; mean age = 12.48; SD = 1.34). In addition, sleep spindles were individually detected and characterized. Compared to boys, girls had significantly greater spindle activity, as reflected in higher NREM sigma power, spindle amplitude, spindle frequency and spindle density over widespread regions. Furthermore, power in higher frequency bands (16.2-44 Hz) was larger in girls than boys in a state independent manner. Oscillatory activity across frequency bands and sleep states was generally more coherent in females as compared to males, suggesting greater connectivity in females. An exception to this finding was the alpha band during NREM and REM sleep, where coherence was higher (NREM) or not different (REM) in boys compared to girls. Sleep spindles are generated through thalamocortical circuits, and thus, the greater spindle activity across regions in females may represent a stronger thalamocortical circuit in adolescent females as compared to males. Moreover, greater global connectivity in females may reflect functional brain differences with implications for cognition and mental health. Given the pronounced gender differences, our study highlights the importance of taking gender into account when designing and interpreting studies of sleep neurophysiology.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Markovic, Andjela; Kaess, Michael and Tarokh, Leila

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Chantal Michel

Date Deposited:

25 Dec 2020 13:19

Last Modified:

27 Dec 2020 02:51

Publisher DOI:

10.1038/s41598-020-72802-0

PubMed ID:

32985555

BORIS DOI:

10.7892/boris.148969

URI:

https://boris.unibe.ch/id/eprint/148969

Actions (login required)

Edit item Edit item
Provide Feedback