Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens

Müller, Stefan; Schaffer, Thomas; Flogerzi, Beatrice; Seibold-Schmid, Beatrice; Schnider, Jasmin; Takahashi, Kazue; Darfeuille-Michaud, Arlette; Vazeille, Emilie; Schoepfer, Alain M; Seibold, Frank (2010). Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens. Gut, 59(11), pp. 1493-500. London: BMJ Publishing Group 10.1136/gut.2010.208348

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In Crohn's disease (CD) the deficiency of mannan-binding lectin (MBL) is associated with an increased prevalence of anti-Saccharomyces cerevisiae antibodies (ASCA) and with complicated phenotypes of the disease. However, the role of MBL in intestinal inflammation is currently unclear. A study was undertaken to analyse local MBL expression in human intestine and the consequences of MBL deficiency in experimental colitis and yeast infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Seibold, Frank Werner

ISSN:

0017-5749

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1136/gut.2010.208348

PubMed ID:

20682699

Web of Science ID:

000282963100012

URI:

https://boris.unibe.ch/id/eprint/1490 (FactScience: 203173)

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