Colella, Fabio; Garcia, João Pedro; Sorbona, Marco; Lolli, Andrea; Antunes, Bernardo; D'Atri, Domenico; Barré, Florian P Y; Oieni, Jacopo; Vainieri, Maria Letizia; Zerrillo, Luana; Capar, Serdar; Häckel, Sonja; Cai, Yunpeng; Creemers, Laura B (2020). Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents. Journal of controlled release, 328, pp. 985-999. Elsevier 10.1016/j.jconrel.2020.08.041
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Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low back pain represent the most common degenerative joint pathologies and are leading causes of pain and disability in adults. Articular cartilage (AC) and intervertebral discs are cartilaginous tissues with a similar biochemical composition and pathophysiological aspects of degeneration. Although treatments directed at reversing these conditions are yet to be developed, many promising disease-modifying drug candidates are currently under investigation. Given the localized nature of these chronic diseases, drug delivery systems have the potential to enhance therapeutic outcomes by providing controlled and targeted release of bioactives, minimizing the number of injections needed and increasing drug concentration in the affected areas. This review provides a comprehensive overview of the currently most promising disease-modifying drugs as well as potential drug delivery systems for OA and IVDD therapy.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Häckel, Sonja |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0168-3659 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Kathrin Aeschlimann |
Date Deposited: |
29 Dec 2020 16:52 |
Last Modified: |
05 Dec 2022 15:42 |
Publisher DOI: |
10.1016/j.jconrel.2020.08.041 |
PubMed ID: |
32860929 |
BORIS DOI: |
10.48350/149049 |
URI: |
https://boris.unibe.ch/id/eprint/149049 |
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