Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality.

Averbuch, Diana; Tridello, Gloria; Hoek, Jennifer; Mikulska, Malgorzata; Pabst, Thomas; Yaňez San Segundo, Lucrecia; Akan, Hamdi; Özçelik, Tülay; Donnini, Irene; Klyasova, Galina; Botelho de Sousa, Aida; Zuckerman, Tsila; Tecchio, Cristina; de la Camara, Rafael; Aki, Sahika Zeynep; Ljungman, Per; Gülbas, Zafer; Nicolas-Virelizier, Emmanuelle; Calore, Elisabetta; Perruccio, Katia; ... (2020). Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality. Journal of infection, 81(6), pp. 882-894. Elsevier 10.1016/j.jinf.2020.11.002

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OBJECTIVES

We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.

METHODS

Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).

RESULTS

The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7-9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5-7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6-7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4-1.1%). GNRB, especially MDR, was associated with increased mortality. Multivariate analysis revealed the following GNRB risk factors: (a) pre-eng-allo-HSCT: south-eastern Europe center location, underlying diseases not at complete remission, and cord blood source; (b) post-eng-allo-HSCT: center location not in northwestern Europe; underlying non-malignant disease, not providing FQP and never accredited. (c) pre-eng-auto-HSCT: older age, autoimmune and malignant (vs. plasma cell) disease, and ICT absence.

CONCLUSIONS

Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Pabst Müller, Thomas Niklaus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0163-4453

Publisher:

Elsevier

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

30 Dec 2020 07:36

Last Modified:

30 Dec 2020 07:45

Publisher DOI:

10.1016/j.jinf.2020.11.002

PubMed ID:

33186673

Uncontrolled Keywords:

Bacteremia Fluoroquinolone prophylaxis Gram-negative Mortality Post-engraftment Pre-engraftment Risk factors Stem cell transplantation

BORIS DOI:

10.48350/149196

URI:

https://boris.unibe.ch/id/eprint/149196

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