Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic Science to Clinics.

Harrell, Carl Randall; Jovicic, Nemanja; Djonov, Valentin; Volarevic, Vladislav (2020). Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic Science to Clinics. Pharmaceutics, 12(5) MDPI 10.3390/pharmaceutics12050474

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Mesenchymal stem cells (MSC) are, due to their immunosuppressive and regenerative properties, used as new therapeutic agents in cell-based therapy of inflammatory and degenerative diseases. A large number of experimental and clinical studies revealed that most of MSC-mediated beneficial effects were attributed to the effects of MSC-sourced exosomes (MSC-Exos). MSC-Exos are nano-sized extracellular vesicles that contain MSC-derived bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs)), enzymes, cytokines, chemokines, and growth factors) that modulate phenotype, function and homing of immune cells, and regulate survival and proliferation of parenchymal cells. In this review article, we emphasized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exos-based beneficial effects in experimental models and clinical trials. Additionally, we elaborated on the challenges of conventional MSC-Exos administration and proposed the use of new bioengineering and cellular modification techniques which could enhance therapeutic effects of MSC-Exos in alleviation of inflammatory and degenerative diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Djonov, Valentin Georgiev and Volarevic, Vladislav

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1999-4923

Publisher:

MDPI

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

10 Dec 2020 17:27

Last Modified:

10 Dec 2020 17:27

Publisher DOI:

10.3390/pharmaceutics12050474

PubMed ID:

32456070

Uncontrolled Keywords:

exosomes inflammation mesenchymal stem cells regeneration therapy

BORIS DOI:

10.7892/boris.149202

URI:

https://boris.unibe.ch/id/eprint/149202

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