Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma.

Harrell, C Randall; Fellabaum, Crissy; Arsenijevic, Aleksandar; Markovic, Bojana Simovic; Djonov, Valentin; Volarevic, Vladislav (2019). Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem cells international, 2019, p. 7869130. Hindawi 10.1155/2019/7869130

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Glaucoma represents a group of progressive optic neuropathies characterized by gradual loss of retinal ganglion cells (RGCs), the neurons that conduct visual information from the retina to the brain. Elevated intraocular pressure (IOP) is considered the main reason for enhanced apoptosis of RGCs in glaucoma. Currently used therapeutic agents are not able to repopulate and/or regenerate injured RGCs and, therefore, are ineffective in most patients with advanced glaucoma. Accordingly, several new therapeutic approaches, including stem cell-based therapy, have been explored for the glaucoma treatment. In this review article, we emphasized current knowledge regarding molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cells (MSCs) and their secretome in the treatment of glaucoma. MSCs produce neurotrophins and in an exosome-dependent manner supply injured RGCs with growth factors enhancing their survival and regeneration. Additionally, MSCs are able to generate functional RGC-like cells and induce proliferation of retinal stem cells. By supporting integrity of trabecular meshwork, transplanted MSCs alleviate IOP resulting in reduced loss of RGCs. Moreover, MSCs are able to attenuate T cell-driven retinal inflammation providing protection to the injured retinal tissue. In summing up, due to their capacity for neuroprotection and immunomodulation, MSCs and their secretome could be explored in upcoming clinical studies as new therapeutic agents for glaucoma treatment.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Djonov, Valentin Georgiev

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1687-966X

Publisher:

Hindawi

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

30 Dec 2020 08:55

Last Modified:

10 Jan 2021 02:51

Publisher DOI:

10.1155/2019/7869130

PubMed ID:

31949441

BORIS DOI:

10.48350/149208

URI:

https://boris.unibe.ch/id/eprint/149208

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