Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; Aplin, Alfred C; Auerbach, Robert; Augustin, Hellmut G; Bates, David O; van Beijnum, Judy R; Bender, R Hugh F; Bergers, Gabriele; Bikfalvi, Andreas; Bischoff, Joyce; Böck, Barbara C; Brooks, Peter C; Bussolino, Federico; Cakir, Bertan; Carmeliet, Peter; Castranova, Daniel; Cimpean, Anca M; ... (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis, 21(3), pp. 425-532. Springer Netherlands 10.1007/s10456-018-9613-x

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The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Djonov, Valentin Georgiev

ISSN:

0969-6970

Publisher:

Springer Netherlands

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

28 Jan 2021 08:52

Last Modified:

28 Jan 2021 09:01

Publisher DOI:

10.1007/s10456-018-9613-x

PubMed ID:

29766399

Uncontrolled Keywords:

Angiogenesis Aortic ring Chorioallantoic membrane (CAM) Corneal angiogenesis Endothelial cell migration Hindlimb ischemia Intussusceptive angiogenesis Microfluidic Myocardial angiogenesis Plug assay Proliferation Recombinant proteins Retinal vasculature Tip cells Vascular network Vessel co-option Zebrafish

BORIS DOI:

10.48350/149267

URI:

https://boris.unibe.ch/id/eprint/149267

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