EphB4 receptor tyrosine kinase transgenic mice develop glomerulopathies reminiscent of aglomerular vascular shunts.

Andres, Anne-Catherine; Munarini, Nadia; Djonov, Valentin; Bruneau, Salomé; Zuercher, Gisela; Loercher, Saemi; Rohrbach, Valeria; Ziemiecki, Andrew (2003). EphB4 receptor tyrosine kinase transgenic mice develop glomerulopathies reminiscent of aglomerular vascular shunts. Mechanisms of development, 120(4), pp. 511-516. Elsevier 10.1016/s0925-4773(02)00461-6

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We have established transgenic mice over-expressing the EphB4 receptor tyrosine kinase in the kidney. The EphB4 protein was localised to the developing tubular system of both control and transgenic newborn mice. In transgenic adults, transgene expression persisted in the proximal tubules and the Bowman's capsules, structures, which were not stained in control kidneys. The glomeruli of control animals consisted of regular, round vascular baskets with clearly discernable afferent and efferent arterioles. In contrast, approximately 40% of the transgenic glomeruli had an irregular shrivelled appearance and many exhibited fused, horse shoe-like afferent and efferent arterioles bypassing the glomerulus. These abnormal glomerular structures are very reminiscent of aglomerular vascular shunts, a human degenerative glomerulopathy of unknown aetiology.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Djonov, Valentin Georgiev

ISSN:

0925-4773

Publisher:

Elsevier

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

04 Feb 2021 14:41

Last Modified:

04 Feb 2021 14:51

Publisher DOI:

10.1016/s0925-4773(02)00461-6

PubMed ID:

12676328

BORIS DOI:

10.48350/149306

URI:

https://boris.unibe.ch/id/eprint/149306

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