The oxysterol receptor GPR183 in inflammatory bowel diseases.

Misselwitz, Benjamin; Wyss, Annika; Raselli, Tina; Cerovic, Vuc; Sailer, Andreas W; Krupka, Niklas; Ruiz, Florian; Pot, Caroline; Pabst, Oliver (2021). The oxysterol receptor GPR183 in inflammatory bowel diseases. British journal of pharmacology, 178(16), pp. 3140-3156. Wiley-Blackwell 10.1111/bph.15311

[img]
Preview
Text
bph.15311.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (1MB) | Preview

Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory bowel disease (IBD). The G-protein-coupled receptor 183 (GPR183, also called EBI2) and its ligands, dihydroxylated oxysterols can mediate positioning of immune cells including innate lymphoid cells (ILCs). GPR183 has been mapped to an IBD risk locus; however, another gene, UBAC2, is encoded on the reverse strand and associated with Behçet's disease and the role of GPR183 as a genetic risk factor requires validation. GPR183 and production of its oxysterol ligands are upregulated in human IBD and murine colitis. Gpr183 inactivation reduced severity of colitis in ILC3-dependent colitis and in IL-10 colitis but not in dextran sodium sulphate colitis. Irrespectively, Gpr183 knockout strongly reduced accumulation of intestinal lymphoid tissue in health and all colitis models. In conclusion, genetic, translational and experimental studies implicate GPR183 in IBD pathogenesis and GPR183-dependent cell migration might be a therapeutic drug target for IBD.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Misselwitz, Benjamin and Krupka, Niklas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-1188

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

18 Dec 2020 17:06

Last Modified:

06 Nov 2021 00:25

Publisher DOI:

10.1111/bph.15311

PubMed ID:

33145756

Uncontrolled Keywords:

EBI2 GPR183 UBAC2 colitis inflammatory bowel diseases innate lymphoid cells oxysterols solitary intestinal lymphoid tissue

BORIS DOI:

10.7892/boris.149310

URI:

https://boris.unibe.ch/id/eprint/149310

Actions (login required)

Edit item Edit item
Provide Feedback