Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Wan, Chenjie; Bachmann, Nadine; Mitov, Venelin; Blanquart, François; Céspedes, Susana Posada; Turk, Teja; Neumann, Kathrin; Beerenwinkel, Niko; Bogojeska, Jasmina; Fellay, Jacques; Roth, Volker; Böni, Jürg; Perreau, Matthieu; Klimkait, Thomas; Yerly, Sabine; Battegay, Manuel; Walti, Laura; Calmy, Alexandra; Vernazza, Pietro; Bernasconi, Enos; ... (2020). Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART. Nature communications, 11(1), p. 5542. Nature Publishing Group 10.1038/s41467-020-19198-7

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The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the long-term HIV-1 reservoir decay. Our findings indicate that viral genetic factors contribute to the HIV-1 reservoir size and hence the infecting HIV-1 strain may affect individual patients' hurdle towards a cure.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Walti, Laura Naëmi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

30 Dec 2020 14:08

Last Modified:

12 Mar 2021 05:25

Publisher DOI:

10.1038/s41467-020-19198-7

PubMed ID:

33139735

BORIS DOI:

10.48350/149327

URI:

https://boris.unibe.ch/id/eprint/149327

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