Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson's disease: a longitudinal study.

Ge, Jingjie; Wang, Min; Lin, Wei; Wu, Ping; Guan, Yihui; Zhang, Huiwei; Huang, Zhemin; Yang, Likun; Zuo, Chuantao; Jiang, Jiehui; Rominger, Axel; Shi, Kuangyu (2020). Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson's disease: a longitudinal study. EJNMMI research, 10(1), p. 131. Springer 10.1186/s13550-020-00722-1

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BACKGROUND

With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson's disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with 18F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD.

METHODS

Age-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent 18F-FDG PET scans. The DBS patients were followed longitudinally to investigate the alternations of the PD-related metabolic covariance pattern (PDRP) expressions.

RESULTS

The PDRP expression was abnormally elevated in PD patients compared with HCs (P < 0.001). For DBS patients, a significant decrease in the Unified Parkinson's Disease Rating Scale (UPDRS, P = 0.001) and PDRP expression (P = 0.004) was observed 3 months after STN DBS treatment, while a rollback was observed in both UPDRS and PDRP expressions (both P < 0.01) 12 months after treatment. The changes in PDRP expression mediated by STN DBS were generally in line with UPDRS improvement. The graphical network analysis shows increased connections at 3 months and a return at 12 months confirmed by small-worldness coefficient.

CONCLUSIONS

The preliminary results demonstrate the potential of metabolic network expression as complimentary objective biomarker for the assessment and monitoring of STN DBS treatment in PD patients. Clinical Trial Registration ChiCTR-DOC-16008645.  http://www.chictr.org.cn/showproj.aspx?proj=13865 .

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver and Shi, Kuangyu

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2191-219X

Publisher:

Springer

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

04 Jan 2021 07:54

Last Modified:

10 Mar 2021 06:51

Publisher DOI:

10.1186/s13550-020-00722-1

PubMed ID:

33119814

Uncontrolled Keywords:

Deep brain stimulation Graph theory PD-related metabolic network pattern Parkinson’s disease Spatial covariance analysis

BORIS DOI:

10.48350/149384

URI:

https://boris.unibe.ch/id/eprint/149384

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