Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.

Förger, Frauke; Villiger, Peter M. (2020). Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity. Nature reviews - rheumatology, 16(2), pp. 113-122. Nature Publishing Group 10.1038/s41584-019-0351-2

Full text not available from this repository.

During pregnancy, the fetus that grows within the maternal uterus is not rejected by the maternal immune system. To enable both tolerance towards the fetus and defence against pathogens, modifications of the maternal immune system occur during gestation. These modifications are able to bring about a natural improvement in disease activity of some autoimmune diseases, such as rheumatoid arthritis (RA). Various mechanisms of the immune system contribute to the phenomenon of pregnancy-related improvement of RA, and the cessation of these immunomodulatory mechanisms after delivery correlates with postpartum disease flare. HLA disparity between mother and fetus, glycosylation of IgG, immunoregulatory pathways, and alterations in innate and adaptive immune cells and their cytokines have important roles in pregnancy and in pregnancy-related amelioration of RA.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
UniBE Contributor:	Förger, Frauke, Villiger, Peter Matthias
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1759-4790
Publisher:	Nature Publishing Group
Language:	English
Submitter:	Marlise Bühler Zimmermann
Date Deposited:	17 Dec 2020 15:00
Last Modified:	05 Dec 2022 15:42
Publisher DOI:	10.1038/s41584-019-0351-2
PubMed ID:	31932747
URI:	https://boris.unibe.ch/id/eprint/149392