Equal rights in autoimmunity: is Sjögren's syndrome ever 'secondary'?

Kollert, Florian; Fisher, Benjamin A (2020). Equal rights in autoimmunity: is Sjögren's syndrome ever 'secondary'? Rheumatology, 59(6), pp. 1218-1225. Oxford University Press 10.1093/rheumatology/keaa009

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Sjögren's syndrome (SjS) accompanied by other systemic autoimmune rheumatic connective tissue diseases has historically been termed 'secondary' in contrast to 'primary' SjS as a standalone entity. However, it is a matter of a long-standing debate whether the prefixes 'primary' and 'secondary', including a temporal component, are obsolete in the terminology of SjS. We review the history and the pathophysiological, chronological, genetic, histological and clinical data underlying the concept of 'secondary' SjS. There are important unintended consequences of the nomenclature; notably 'secondary' SjS has been much less researched and is often excluded from clinical trials. We argue for further research, a change in terminology and more stringent classification. Further we highlight possible opportunities for trials in SjS and other systemic autoimmune diseases that might contribute to an advance in care for all patients with SjS.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Kollert, Florian Kim

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1462-0324

Publisher:

Oxford University Press

Language:

English

Submitter:

Marlise Bühler Zimmermann

Date Deposited:

23 Dec 2020 15:20

Last Modified:

23 Dec 2020 15:20

Publisher DOI:

10.1093/rheumatology/keaa009

PubMed ID:

32025734

Uncontrolled Keywords:

RA SLE Sjögren’s syndrome anti-Ro antibodies clinical trials genetics histology salivary glands systemic sclerosis

BORIS DOI:

10.48350/149399

URI:

https://boris.unibe.ch/id/eprint/149399

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