The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation.

Li, Yuanyuan; Han, Hongbin; Shi, Kuangyu; Cui, Dehua; Yang, Jun; Alberts, Ian Leigh; Yuan, Lan; Zhao, Guomei; Wang, Rui; Cai, Xianjie; Teng, Ze (2020). The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation. Aging and disease, 11(6), pp. 1407-1422. Aging and Disease 10.14336/AD.2020.0224

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The drainage of brain interstitial fluid (ISF) has been observed to slow down following neuronal excitation, although the mechanism underlying this phenomenon is yet to be elucidated. In searching for the changes in the brain extracellular space (ECS) induced by electrical pain stimuli in the rat thalamus, significantly decreased effective diffusion coefficient (DECS) and volume fraction (α) of the brain ECS were shown, accompanied by the slowdown of ISF drainage. The morphological basis for structural changes in the brain ECS was local spatial deformation of astrocyte foot processes following neuronal excitation. We further studied aquaporin-4 gene (APQ4) knockout rats in which the changes of the brain ECS structure were reversed and found that the slowed DECS and ISF drainage persisted, confirming that the down-regulation of ISF drainage following neuronal excitation was mainly attributable to the release of neurotransmitters rather than to structural changes of the brain ECS. Meanwhile, the dynamic changes in the DECS were synchronized with the release and elimination processes of neurotransmitters following neuronal excitation. In conclusion, the downregulation of ISF drainage following neuronal excitation was found to be caused by the restricted diffusion in the brain ECS, and DECS mapping may be used to track the neuronal activity in the deep brain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Shi, Kuangyu and Alberts, Ian Leigh

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2152-5250

Publisher:

Aging and Disease

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

04 Jan 2021 09:38

Last Modified:

04 Jan 2021 09:38

Publisher DOI:

10.14336/AD.2020.0224

PubMed ID:

33269097

Uncontrolled Keywords:

brain extracellular space interstitial fluid neuronal excitation neurotransmitters tracer-based MRI

BORIS DOI:

10.48350/149409

URI:

https://boris.unibe.ch/id/eprint/149409

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