[Fetal programming of cardiovascular disease: new causes and underlying mechanisms]

Sartori, C; Rexhaj, E; Rimoldi, S F; Allemann, Y; Scherrer, U (2012). [Fetal programming of cardiovascular disease: new causes and underlying mechanisms]. Revue médicale suisse, 8(353), 1716, 1718-24. Genève: Médecine & Hygiène

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There exists an association between pathologic events occurring during early life and the development of cardiovascular disease in adulthood. For example, transient perinatal hypoxemia predisposes to exaggerated hypoxic pulmonary hypertension and preeclampsia predisposes the offspring to pulmonary and systemic endothelial dysfunction later in life. The latter finding offers a scientific basis for observations demonstrating an increased risk for premature cardiovascular morbidity in this population. Very recently, we showed that offspring of assisted reproductive technologies also display generalized vascular dysfunction and early arteriosclerosis. Studies in animal models have provided evidence that oxidative stress and/or epigenetic alterations play an important pathophysiological role in the fetal programming of cardiovascular disease.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Rexhaj, Emrush; Rimoldi, Stefano; Allemann, Yves and Scherrer, Urs

ISSN:

0025-6749

Publisher:

Médecine & Hygiène

Language:

French

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:37

Last Modified:

06 Dec 2013 13:36

PubMed ID:

23029985

URI:

https://boris.unibe.ch/id/eprint/14946 (FactScience: 222089)

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