Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters.

Linde, Lukas D; Haefeli, Jenny; Jutzeler, Catherine R; Rosner, Jan; McDougall, Jessica; Curt, Armin; Kramer, John L K (2019). Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters. Frontiers in human neuroscience, 13, p. 459. Frontiers Research Foundation 10.3389/fnhum.2019.00459

Linde__2020__Contact_Heat.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (4MB) | Preview

The sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latencies). The aim of this study was to investigate contact heat stimulation parameters necessary to detect peripheral sensitization related to the topical application of capsaicin, and therefore significantly improve the current method of measuring peripheral sensitization via CHEPs. Rapid contact heat stimulation (70°C/s) was applied from three different baseline temperatures (35, 38.5, and 42°C) to a 52°C peak temperature, before and after the topical application of capsaicin on the hand dorsum. Increased pain ratings in the primary area of hyperalgesia were accompanied by reduced N2 latency. Changes in N2 latency were, however, only significant following stimulation from 35 and 38.5°C baseline temperatures. These findings suggest that earlier recruitment of capsaicin-sensitized afferents occurs between 35 and 42°C, as stimulations from 42°C baseline were unchanged by capsaicin. This is in line with reduced thresholds of type II A-delta mechanoheat (AMH) nociceptors following sensitization. Conventional CHEP stimulation, with a baseline temperature below 42°C, is well suited to objectively detect evidence of peripheral sensitization.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Rosner, Jan


600 Technology > 610 Medicine & health




Frontiers Research Foundation




Chantal Kottler

Date Deposited:

04 Jan 2021 15:29

Last Modified:

14 Mar 2021 05:57

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

EEG capsaicin contact heat evoked potentials hyperalgesia type II A mechanoheat nociceptors




Actions (login required)

Edit item Edit item
Provide Feedback