Sleep neurophysiology in childhood onset schizophrenia

Markovic, Andjela; Buckley, Ashura; Driver, David I.; Dillard‐Broadnax, Diane; Gochman, Peter A.; Hoedlmoser, Kerstin; Rapoport, Judith L.; Tarokh, Leila (2021). Sleep neurophysiology in childhood onset schizophrenia. Journal of sleep research, 30(2), e13039. Wiley-Blackwell 10.1111/jsr.13039

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Altered sleep neurophysiology has consistently been reported in adult patients with schizophrenia. Converging evidence suggests that childhood onset schizophrenia (COS), a rare but severe form of schizophrenia, is continuous with adult onset schizophrenia. The aim of the current study was to characterize sleep neurophysiology in COS. An overnight sleep electroencephalogram (EEG) was recorded in 17 children and adolescents with COS (16 years ± 6.6) and 17 age and gender-matched controls. Non-rapid eye movement (NREM) and rapid eye movement (REM) sleep EEG power and coherence for the frequency bands delta (1.6-4.8 Hz), theta (5-8.4 Hz), alpha (8.6-11 Hz), beta 1 (16.4-20.2 Hz) and beta 2 (20.4-24.2 Hz) were compared between COS patients and controls. COS patients exhibited significant and widespread deficits in beta power during NREM and REM sleep. With regard to coherence, we found increases in COS patients across brain regions, frequency bands and sleep states. This study demonstrates the utility of the sleep EEG for studying vulnerable populations and its potential to aid diagnosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Markovic, Andjela and Tarokh, Leila

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0962-1105

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Chantal Michel

Date Deposited:

04 Jan 2021 12:05

Last Modified:

27 Mar 2021 01:32

Publisher DOI:

10.1111/jsr.13039

PubMed ID:

32350968

BORIS DOI:

10.48350/149477

URI:

https://boris.unibe.ch/id/eprint/149477

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