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h
f
Q
q
1 0 0 1 494.8578 757.0725 cm
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h
f
Q
q
1 0 0 1 497.7328 757.027 cm
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2.15 1.644 1.774 1.815 1.382 1.797 c
1.156 1.805 0.931 1.75 0.734 1.64 c
0.559 1.536 0.411 1.395 0.299 1.225 c
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3.827 -2.435 m
2.789 -2.435 l
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0.578 2.633 0.847 2.683 1.119 2.683 c
1.277 2.683 1.434 2.67 1.589 2.642 c
1.748 2.613 1.902 2.565 2.05 2.5 c
2.197 2.438 2.334 2.356 2.46 2.257 c
2.584 2.16 2.69 2.042 2.774 1.908 c
2.774 4.439 l
3.872 4.439 l
3.872 -2.435 l
h
f
Q
q
1 0 0 1 505.8212 757.0877 cm
0 0 m
-0.186 -0.116 -0.398 -0.183 -0.617 -0.197 c
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0.005 -0.005 l
h
1.098 -1.387 m
1.09 -1.486 1.107 -1.585 1.149 -1.675 c
1.198 -1.739 1.277 -1.772 1.357 -1.761 c
1.473 -1.761 l
1.524 -1.767 1.574 -1.767 1.625 -1.761 c
1.625 -2.521 l
1.478 -2.566 l
1.291 -2.607 l
1.098 -2.637 l
0.936 -2.637 l
0.742 -2.644 0.549 -2.596 0.38 -2.5 c
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0.04 0.793 0.084 0.922 0.076 1.053 c
0.081 1.176 0.045 1.296 -0.025 1.397 c
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-0.632 2.632 -0.39 2.607 -0.152 2.556 c
0.073 2.51 0.289 2.426 0.486 2.308 c
0.67 2.197 0.826 2.044 0.941 1.863 c
1.061 1.661 1.121 1.429 1.114 1.195 c
1.114 -1.362 l
h
f
Q
q
1 0 0 1 507.6029 759.5628 cm
0 0 m
0.825 0 l
0.825 1.493 l
1.898 1.493 l
1.898 0 l
2.91 0 l
2.91 -0.82 l
1.898 -0.82 l
1.898 -3.472 l
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1.904 -3.846 1.926 -3.918 1.964 -3.983 c
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2.213 -4.148 2.311 -4.164 2.409 -4.161 c
2.642 -4.161 l
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2.875 -4.97 l
2.521 -5.011 l
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0.79 -0.815 l
-0.035 -0.815 l
-0.035 0 l
h
f
Q
q
1 0 0 1 514.7145 757.5129 cm
0 0 m
-0.012 0.173 -0.05 0.344 -0.111 0.506 c
-0.168 0.66 -0.252 0.803 -0.359 0.926 c
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0.015 0.02 l
h
-2.556 -0.719 m
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1.028 -1.362 l
0.924 -1.867 0.635 -2.314 0.218 -2.617 c
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0.105 1.808 0.37 1.586 0.577 1.316 c
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1.116 0.037 1.139 -0.331 1.093 -0.693 c
-2.561 -0.693 l
h
f
Q
q
1 0 0 1 517.4781 756.1766 cm
0 0 m
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1.969 0.203 1.842 0.277 1.706 0.324 c
1.541 0.383 1.372 0.431 1.2 0.466 c
0.628 0.628 l
0.427 0.671 0.23 0.725 0.035 0.79 c
-0.145 0.85 -0.316 0.937 -0.471 1.048 c
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-0.053 3.328 0.175 3.406 0.41 3.447 c
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1.366 3.514 1.612 3.487 1.853 3.432 c
2.077 3.381 2.291 3.292 2.485 3.169 c
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3.089 2.478 3.17 2.235 3.194 1.984 c
2.05 1.984 l
2.018 2.201 1.884 2.389 1.691 2.49 c
1.487 2.583 1.266 2.63 1.043 2.627 c
0.952 2.632 0.861 2.632 0.769 2.627 c
0.667 2.615 0.567 2.592 0.471 2.556 c
0.381 2.524 0.3 2.472 0.233 2.404 c
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0.385 1.72 0.509 1.65 0.643 1.604 c
0.808 1.545 0.977 1.498 1.149 1.463 c
1.746 1.336 l
1.945 1.292 2.141 1.238 2.333 1.174 c
2.514 1.114 2.685 1.027 2.84 0.916 c
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3.354 -0.36 3.284 -0.621 3.143 -0.845 c
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0.035 0.015 l
h
f
Q
0.146 0.939 1 0.048 k
q
1 0 0 1 421.0242 753.4889 cm
0 0 m
6.884 4.586 l
6.884 10.093 l
0 10.093 l
h
f
Q
0 0.891 0.683 0 k
q
1 0 0 1 427.908 753.4889 cm
0 0 m
-6.884 4.586 l
-6.884 10.093 l
0 10.093 l
h
f
Q
0.688 0.074 0.203 0 k
q
1 0 0 1 424.4661 751.4542 cm
0 0 m
-3.167 0 -5.735 2.568 -5.735 5.735 c
-5.735 8.902 -3.167 11.47 0 11.47 c
3.167 11.47 5.735 8.902 5.735 5.735 c
5.735 2.568 3.167 0 0 0 c
0 13.327 m
-4.193 13.327 -7.592 9.928 -7.592 5.735 c
-7.592 1.542 -4.193 -1.858 0 -1.858 c
4.193 -1.858 7.592 1.542 7.592 5.735 c
7.592 9.928 4.193 13.327 0 13.327 c
f
Q
0 0.241 0.862 0 k
q
1 0 0 1 428.6723 753.3067 cm
0 0 m
-2.138 -2.329 -5.76 -2.484 -8.089 -0.345 c
-9.846 1.268 -10.418 3.801 -9.526 6.013 c
-11.115 7.026 l
-12.837 3.202 -11.134 -1.293 -7.311 -3.015 c
-4.227 -4.404 -0.595 -3.586 1.594 -1.007 c
h
f
Q
Q
0.05 0.05 0.05 0.05 k
0.15 0.15 0.15 0.15 K
0.5 w
4 M
/GS0 gs
306.388 412.939 238.638 170.081 re
B
BT
0 0 0 1 k
/GS1 gs
/TT1 1 Tf
10.815 0 0 10.5 310.3878 570.8196 Tm
[ (S) 0.5 (IGNIFICANCE) ] TJ
/TT0 1 Tf
0.067 Tw
7.8 0 0 7.8 310.3878 555.4196 Tm
[ (Sk) 0.6 (in ) 0.8 (in) 9.9 (v) 9 (olv) 9 (em) 0.6 (en) 0.5 (t ) 0.8 (in ) 0.8 (W) 49.1 (alden) 0.5 (str\366m\222) 34.6 (s ) 0.8 (macroglobulinaem) 1.1 (ia ) 1.3 (is ) ] TJ
-0.04 Tw
0 -1.462 Td
[ (poorly described\054 ) 0.6 (an) 0.6 (d diagnosis of ) 0.8 (this disorder) 0.5 ( ma) 8.3 (y be ) 0.6 (dif) ] TJ
0 Tw
7.8 0 0 7.8 537.4836 544.0197 Tm
(\055) Tj
/C2_0 1 Tf
7.8 0 0 7.8 310.3878 532.6196 Tm
[ <00bf00460058004f005700110003> -24.9 <003000440051> 10.4 <005c0003> -25.2 <0047004c0049004900480055> 1.5 <004800510057004c0044004f0003> -25.2 <0047004c0044004a005100520056004800560003> -25.2 <00440055> 0.7 <00480003> -24.9 <0053005200560056004c0045004f00480003> -24.9 <000b00520057004b00480055> 0.5 <0003> -25.2 <004f005c0050> ] TJ
/TT0 1 Tf
7.8 0 0 7.8 537.4836 532.6196 Tm
(\055) Tj
/C2_0 1 Tf
7.8 0 0 7.8 310.3878 521.2197 Tm
[ <0053004b0052005000440056000f0003> 24.7 <00530055004c005000440055> 0.7 <005c0003> 24.5 <00460058005700440051> 0.6 <00480052005800560003> 24.5 <004f005c00500053004b005200500044000f0003> 25.2 <0048005700460011000c00110003> 24.9 <0027> 0.5 <0048005600460055004c0045004c0051004a0003> 24.5 <00150003> ] TJ
0 -1.462 Td
[ <00440056005300480046005700560003> -99.1 <005200490003> -98.6 <003a> 49 <0044004f004700480051005600570055007c005000b6> 34.6 <00560003> -99.1 <00500044004600550052004a004f005200450058004f004c0051004400480050> 1.1 <004c00440003> -98.7 <000b004c005100bf004f00570055> 17.8 <00440057004c005200510003> ] TJ
/TT0 1 Tf
-0.038 Tw
0 -1.462 Td
[ (b) 2.4 (y lymphoplasmacytic tumour cells or histological tr) 17.9 (an) 0.6 (sfo) 0.5 (r) ] TJ
0 Tw
7.8 0 0 7.8 537.4836 498.4196 Tm
(\055) Tj
/C2_0 1 Tf
7.8 0 0 7.8 310.3878 487.0197 Tm
[ <005000440057004c005200510003> 43 <004c0051005700520003> 43.1 <0047004c004900490058> 1 <005600480003> 43.4 <004f00440055> 0.7 <004a00480003> 43.4 <0025> -4.4 <001000460048004f004f0003> 43.1 <004f005c00500053004b005200500044000c0003> 43.4 <0044004f004f0052005a00560003> 43.1 <0057004b00480003> 43.4 <004c004700480051> ] TJ
/TT0 1 Tf
7.8 0 0 7.8 537.4836 487.0197 Tm
(\055) Tj
/C2_0 1 Tf
7.8 0 0 7.8 310.3878 475.6196 Tm
[ <0057004c00bf004600440057004c005200510003> -83.2 <005200490003> -82.7 <0046004f004c0051004c00460044004f000f0003> -83 <004b004c005600570052004f0052004a004c00460044004f0003> -83.2 <0044005100470003> -83.2 <004c00500050005800510052004b004c0056005700520046004b00480050> 0.7 <004c00460044004f0003> ] TJ
0 -1.462 Td
[ <0047004c0044004a0051005200560057004c00460003> -8.4 <0044004c0047005600110003> -8.1 <0027> 0.5 <00480057004800460057004c005200510003> -8.3 <005200490003> -7.9 <0057004b00480003> ] TJ
/TT2 1 Tf
16.622 0 Td
(MYD88) Tj
/C2_0 1 Tf
[ <0003> -8.4 <002f0015> 0.6 <0019001800330003> -8.4 <00500058005700440057004c005200510003> -8.4 <004c00560003> ] TJ
-16.622 -1.462 Td
[ <005200490003> 46.9 <004c0051005700480055> 0.6 <00480056005700110003> 46.8 <0037004b004c00560003> 46.5 <0056005700580047005c0003> 46.6 <004c004700480051> 0.5 <0057004c00bf004800470003> 46.5 <00440003> 46.5 <0046004b00440055> 18.2 <00440046> 0.5 <005700480055> 0.5 <004c00560057004c00460003> 46.5 <0046004f004c0051004c00460044004f0003> 46.5 <0053004c0046> ] TJ
/TT0 1 Tf
7.8 0 0 7.8 537.4836 452.8196 Tm
(\055) Tj
/C2_0 1 Tf
7.8 0 0 7.8 310.3878 441.4196 Tm
[ <00570058005500480003> 9.4 <004c00510003> 9.1 <005100520051001000570055> 17.9 <00440051> 0.6 <005600490052> 0.5 <00550050004800470003> 9.1 <00460044005600480056000f0003> 9.3 <00440051> 0.6 <00470003> 9.1 <005a> 9.4 <004400560003> 9.1 <00440045004f00480003> 9.3 <005700520003> 9 <0047004c00560057004c0051004a0058004c0056004b0003> ] TJ
0 -1.462 Td
[ <004500480057005a004800480051> 0.8 <0003> -75.7 <00570055> 17.9 <00440051> 0.6 <005600490052> 0.5 <00550050004800470003> -75.8 <00440051> 0.7 <00470003> -75.8 <005100520051001000570055> 17.9 <00440051> 0.6 <005600490052> 0.5 <00550050004800470003> -75.7 <004600440056004800560003> -75.8 <0045> 2.4 <005c0003> -75.7 <0057004b0048004c00550003> ] TJ
0 -1.462 Td
[ <005600480059> 9.3 <00480055> 0.5 <004c0057> 4.9 <005c000300440051> 1 <0047000300530052005200550003005300550052004a005100520056004c00560011> ] TJ
/TT3 1 Tf
-0.06 Tw
-33.383 20.344 Td
[ (Cutaneous invo) 0.5 (lvement) 0.5 ( in Waldenstr\366) 0.5 (m\222s macro) 0.5 (glo) 0.6 (bu) ] TJ
0 Tw
7.8 0 0 7.8 284.894 577.3054 Tm
(\055) Tj
0.023 Tw
7.8 0 0 7.8 50 565.9053 Tm
[ (linaemia \050WM\051 has been) -0.6 ( po) 0.5 (o) 0.5 (rly ch) -0.8 (aracteriz) 0.6 (ed\056 To) 0.5 ( des) ] TJ
0 Tw
7.8 0 0 7.8 284.894 565.9053 Tm
(\055) Tj
0.007 Tw
7.8 0 0 7.8 50 554.5053 Tm
[ (cribe this invo) 0.5 (lvement\054 a retro) 0.5 (spective study o) 0.5 (f 19 pa) ] TJ
0 Tw
7.8 0 0 7.8 284.894 554.5053 Tm
(\055) Tj
0.053 Tw
7.8 0 0 7.8 50 543.1053 Tm
[ (tients wit) 0.7 (h WM and cu) -0.8 (taneous invo) 0.5 (lvement) 0.5 ( o) 0.5 (f ) -0.6 (t) 0.5 (umour ) ] TJ
0.042 Tw
0 -1.462 Td
[ (B cells was performed\056 Twelve patient) 0.5 (s \050gro) 0.5 (up 1\051 had ) ] TJ
0.007 Tw
0 -1.462 Td
[ (lympho) 0.5 (plasmacytic\054 no) 0.5 (n\055transformed cu) -0.8 (taneous pro) 0.5 (li) ] TJ
0 Tw
7.8 0 0 7.8 284.894 520.3054 Tm
(\055) Tj
-0.034 Tw
7.8 0 0 7.8 50 508.9053 Tm
[ (ferat) 0.5 (io) 0.7 (n\054 while ) 0.6 (in 7 cases \050group 2\051 cu) -0.7 (taneous invo) 0.5 (lve) ] TJ
0 Tw
7.8 0 0 7.8 284.894 508.9053 Tm
(\055) Tj
0.127 Tw
7.8 0 0 7.8 50 497.5053 Tm
[ (ment) 0.5 ( corresponded to) 0.5 ( histolo) 0.7 (gical t) 0.5 (ransformat) 0.5 (io) 0.7 (n\056 In ) ] TJ
0.176 Tw
0 -1.462 Td
[ (gro) 0.5 (up 1\054 ) -0.6 (skin invo) 0.5 (lvement was inaugural in 6 cases\056 ) ] TJ
/C2_1 1 Tf
0 Tw
0 -1.462 Td
[ <0037004b00480003> -214.4 <004f00480056004c0052> 0.7 <005100560003> -214.6 <005a0048005500480003> -214.4 <004c005100bf004f0057> 1.1 <005500440057004800470003> -214.3 <0053004f004400540058004800560003> -214.6 <000b001b00160008000c000f0003> -214.7 <0053004400530058004f004800560003> ] TJ
0 -1.462 Td
[ <000b001500180008000c0003> -55.2 <0044005100470003> -55.3 <0057> 0.5 <0058005000520058005500560003> -55.6 <000b001700150008000c00110003> -55.6 <00290052> 0.5 <005800550003> -55.3 <005300440057> 0.5 <004c004800510057> 0.5 <00560003> -55.6 <004b004400470003> -55.2 <00440003> -55.3 <0056004c0050004c> ] TJ
/TT3 1 Tf
7.8 0 0 7.8 284.894 463.3053 Tm
(\055) Tj
-0.004 Tw
7.8 0 0 7.8 50 451.9053 Tm
[ (lar clinical picture \050purplish\054 ) -0.6 (bila) 0.5 (teral and symmetrical ) ] TJ
/C2_1 1 Tf
0 Tw
0 -1.462 Td
[ <004c005100bf004f0057> 1.1 <005500440057004c0052> 0.7 <00510003> -144.5 <0052> 0.5 <00510003> -144.5 <0057> 0.5 <004b00480003> -144.5 <0049004400460048000c> -0.9 <00110003> ] TJ
/TT4 1 Tf
14.365 0 Td
(MYD88) Tj
/TT3 1 Tf
0.145 Tw
[ ( ) 0.5 (L265P ) 0.6 (mutat) 0.5 (io) 0.6 (n ) 0.6 (was ) ] TJ
0.124 Tw
-14.365 -1.462 Td
[ (detected ) 0.5 (in ) 0.6 (t) 0.5 (he ) 0.6 (skin ) 0.6 (bio) 0.6 (psy ) 0.6 (in ) 0.5 (all ) 0.9 (6 ) 0.6 (cases t) 0.5 (ested\056 The ) ] TJ
/C2_1 1 Tf
0 Tw
0 -1.462 Td
[ <00160010005c0048004400550003> -22.5 <0056005300480046004c00bf00460003> -22.7 <00560058> -0.6 <00550059004c00590044004f0003> -22.3 <00550044005700480003> -22.6 <005a004400560003> -22.8 <001b001b000800110003> -22.8 <002c00510003> -22.5 <004a00550052> 0.5 <005800530003> -22.5 <0015000f0003> -22.8 <00460058> ] TJ
/TT3 1 Tf
7.8 0 0 7.8 284.894 417.7053 Tm
(\055) Tj
0.315 Tw
7.8 0 0 7.8 50 406.3053 Tm
[ (taneous transformatio) 0.7 (n ) 0.6 (o) 0.5 (ccu) -1.2 (rred ) 0.6 (during ) 0.5 (t) 0.5 (he ) 0.5 (follo) 0.9 (w\055) ] TJ
/C2_1 1 Tf
0 Tw
0 -1.462 Td
[ <005800530003> -107.4 <0052> 0.5 <00490003> -107.7 <0057> 0.5 <004b00480003> -107.4 <003a00300003> -107.3 <000b001a00140008000c00110003> -107.6 <002f00480056004c0052005100560003> -107.6 <005300550048005600480051> -0.8 <0057004800470003> -107.3 <004400560003> -107.6 <0058004f00460048005500440057004800470003> ] TJ
0 -1.462 Td
[ <0057005800500052> 0.5 <0058005500560003> -163.9 <000b001b00190008000c0003> -163.7 <005200490003> -164 <0057004b00480003> -163.8 <0057005500580051004e0003> -163.8 <000b0018001a0008000c0003> -163.7 <0044005100470003> -163.7 <004f0052> 0.6 <005a004800550003> -163.7 <004f004c0050004500560003> ] TJ
0 -1.462 Td
[ <000b0018001a0008000c00110003> -299.2 <0037004b00480003> -299 <00160010005c0048004400550003> -298.8 <0056005300480046004c00bf00460003> -299.1 <00560058> -0.6 <00550059004c00590044004f0003> -298.7 <005500440057> 0.5 <00480003> -299 <005a004400560003> -299.1 <00150015000800110003> ] TJ
/TT3 1 Tf
0.245 Tw
0 -1.462 Td
[ (Skin invo) 0.5 (lvement in WM has distinctive ch) -0.8 (aracteris) ] TJ
0 Tw
7.8 0 0 7.8 284.894 360.7053 Tm
(\055) Tj
0.208 Tw
7.8 0 0 7.8 50 349.3053 Tm
[ (tics \050e\056g) -0.7 (\056 clinical\054 histo) 0.5 (lo) 0.6 (gical\054 immunohisto) 0.5 (ch) -0.8 (emical\054 ) ] TJ
/TT4 1 Tf
0 Tw
0 -1.462 Td
(MYD88) Tj
/TT3 1 Tf
[ ( L265P mutat) 0.5 (io) 0.6 (n\051\056) ] TJ
/TT2 1 Tf
0.508 Tw
7.5 0 0 7.5 50 320.9053 Tm
[ (Key ) 0.6 (words\072 ) ] TJ
/TT0 1 Tf
[ (W) 49.1 (aldenstr\366m\222) 35.3 (s macroglobulinaemia\073 ) 0.8 (cutaneous ) ] TJ
0.159 Tw
0 -1.2 Td
[ (lymphoma\073 ) 1.3 (diffuse ) 1.3 (large ) 0.8 (B) -4.4 (\055cell lymphoma\073 ) 1.5 (histological ) -0.7 (tr) 17.8 (ans) ] TJ
0 Tw
31.364 0 Td
(\055) Tj
-31.364 -1.2 Td
[ (formation\073 extr) 19.9 (anodal in) 10.6 (v) 9 (olv) 8.6 (ement\073 ) ] TJ
/TT2 1 Tf
18.294 0 Td
(MYD88) Tj
/C2_0 1 Tf
3.495 0 Td
<0003002f0015001900180033000300500058005700440057004c005200510011> Tj
-21.79 -2.267 Td
[ <00240046004600480053005700480047000300300044> 9.8 <005c00030014001c000f00030015001300150013001e0003002800530058004500030044004b004800440047000300520049000300530055004c00510057000300300044> 14.8 <005c000300150018000f00030015001300150013> ] TJ
0 -2.267 Td
[ <00240046005700440003002700480055005000030039> 52.3 <004800510048005500480052004f00030015001300150013001e0003001400130013001d0003004400470059001300130015001500180011> ] TJ
/TT2 1 Tf
6.5 0 0 6.5 50 253.1053 Tm
(Corr\072) Tj
/C2_0 1 Tf
[ <0003> -81.5 <003600440055> 18.7 <0044004b0003> -81.3 <00360057004c00480051000f0003> -80.8 <00270048005300440055005700500048005100570003> -79.4 <005200490003> -81 <00320051004600520047004800550050004400570052004f0052004a005c> 94 <000f0003> -81.2 <0035> 24.1 <005200450048005500570003> -81 <002700480045005500700003> -80.2 <002b00520056> ] TJ
/TT0 1 Tf
(\055) Tj
/C2_0 1 Tf
0 -1.2 Td
[ <0053004c00570044004f000f0003> -25.2 <0044> 8.2 <0059> 9 <00480051005800480003> -23.9 <004700580003> -24.8 <002a0070005100700055> 18.3 <0044004f0003> -24.9 <002e> 34.3 <005200480051004c004a000f0003> -24.6 <00290035> 48.8 <001000180014> 0.5 <0013001c00150003> -24.2 <0035> 24.1 <0048004c005000560003> -24.7 <0026004800470048005b000f0003> -24.1 <00290055> 18.1 <004400510046004800110003> -23.8 <0028> ] TJ
/Span <<
/ActualText (\376\377\000\255)
>> BDC
<0003> Tj
EMC
34.137 0 Td
<00500044004c004f001d0003> Tj
-34.137 -1.2 Td
[ <005600440055> 18.2 <0044004b001100560057004c004800510023004a00500044004c004f0011004600520050> ] TJ
/TT5 1 Tf
29.4826 0 0 28.6239 50 193.5053 Tm
(W) Tj
-0.05 Tw
10.815 0 0 10.5 77.8271 205.5053 Tm
[ (aldenstr\366m\222) 55.1 (s macroglobulinaemia \050WM\051 is a rare ) ] TJ
-0.002 Tc
-0.063 Tw
0 -1.143 Td
[ (B\055) 0.5 (c) 0.5 (e) 0.6 (l) 0.6 (l) 0.6 ( l) 0.6 (ym) 0.7 (phopr) 0.5 (ol) 0.6 (i) 0.6 (fe) 0.6 (ra) 0.6 (t) 0.6 (i) 0.6 (ve) 0.6 ( di) 0.6 (sord) 0.5 (e) 0.6 (r c) 0.6 (ha) 0.6 (ra) 0.6 (c) 0.6 (t) 0.6 (e) 0.5 (r) 0.5 (i) 0.6 (z) 0.5 (e) 0.6 (d) -2 ( ) ] TJ
/C2_2 1 Tf
0 Tc
0 Tw
-2.573 -1.143 Td
[ <0045005c0003> 34.6 <004f005c00500053004b00520053004f00440056005000440046005c0057004c00460003> 34.6 <00450052005100480003> 34.6 <00500044005500550052005a0003> 34.6 <004c005100bf004f0057005500440057004c005200510003> 34.6 <0044005100470003> 34.6 <0057004b00480003> ] TJ
/TT5 1 Tf
-0.001 Tc
-0.063 Tw
0 -1.143 Td
[ (presence of a serum monoclonal immunoglobulin \050Ig\051M) -1.1 ( ) ] TJ
0 Tc
0.001 Tw
0 -1.143 Td
[ (paraprotein\056 ) 17.7 (WM accounts for 1\2262\045 of haematological ) ] TJ
/C2_2 1 Tf
-0.011 Tc
0.011 Tw
0 -1.143 Td
[ <0050> 0.7 <0044> 0.7 <004f> 0.7 <004c> 0.7 <004a> 0.5 <0051> 0.5 <0044> 0.7 <0051> 0.6 <0046> 0.6 <004c> 0.7 <0048> 0.7 <00560003> 63 <000b> 0.5 <0014> 0.6 <000f> 0.5 <0003> 63 <0015> 0.6 <000c> 0.5 <0011> 0.5 <0003> 63 <0026> 0.6 <0058> 0.5 <0057> 0.7 <0044> 0.7 <0051> 0.5 <0048> 0.7 <0052> 0.5 <0058> 0.6 <00560003> 63.1 <004f> 0.7 <0048> 0.7 <0056004c> 0.7 <0052> 0.5 <0051> 0.6 <00560003> 63.1 <00560053> 0.5 <0048> 0.7 <0046> 0.6 <004c> 0.7 <00bf0046> 0.7 <0003> 63 <0057> 0.7 <0052> 0.6 <0003> 81.1 <003a> 0.6 <00300003> 63.1 <004c> 0.6 <0051> ] TJ
/TT5 1 Tf
0 Tc
0 Tw
10.815 0 0 10.5 285.0363 145.5053 Tm
(\055) Tj
-0.005 Tc
-0.062 Tw
10.815 0 0 10.5 50 133.5053 Tm
(clude cutaneous macroglobulinosis and cutaneous invol) Tj
0 Tc
0 Tw
10.815 0 0 10.5 285.0363 133.5053 Tm
(\055) Tj
-0.007 Tc
-0.063 Tw
10.815 0 0 10.5 50 121.5053 Tm
[ (ve) 0.5 (m) 0.5 (ent) 0.5 ( of ne) 0.5 (opl) 0.5 (a) 0.5 (st) 0.5 (i) 0.5 (c) 0.5 ( ce) 0.5 (l) 0.5 (ls\056 Cut) 0.5 (a) 0.5 (ne) 0.5 (ous m) 0.5 (a) 0.5 (c) 0.5 (rogl) 0.5 (obul) 0.5 (inosi) 0.5 (s) -7.2 ( ) ] TJ
0.004 Tc
0.125 Tw
0 -1.143 Td
[ (results from cutaneous IgM deposits\054 leading to IgM) 3.8 ( ) ] TJ
-0.01 Tc
-0.062 Tw
0 -1.143 Td
[ (s) -0.6 (torage papules) -0.6 ( \0503\051\056 Cutaneous) -0.6 ( involvement of neo) ] TJ
/Span <<
/ActualText (\376\377\000\255)
>> BDC
( ) Tj
EMC
19.512 0 Td
[ (plas) -0.6 (tic) -9.8 ( ) ] TJ
/C2_2 1 Tf
0 Tc
0 Tw
-19.512 -1.143 Td
[ <00460048004f004f00560003> 35.9 <004c00510046004f00580047004800560003> 35.9 <00470048005500500044004f0003> 35.9 <004c005100bf004f0057005500440057004c005200510003> 36 <0045005c0003> 35.9 <004f005c00500053004b00520053004f0044005600500044> ] TJ
/Span <<
/ActualText (\376\377\000\255)
>> BDC
<0003> Tj
EMC
20.122 0 Td
<0046005c0057004c00460003> Tj
/TT5 1 Tf
-0.007 Tc
-0.063 Tw
-20.122 -1.143 Td
[ (t) 0.6 (u) 0.5 (m) 0.6 (o) 0.5 (ur) 0.5 ( c) 0.6 (e) 0.6 (l) 0.7 (l) 0.6 (s a) 0.7 (nd) 0.5 (\057) 0.6 (o) 0.5 (r hi) 0.6 (st) 0.7 (ol) 0.6 (o) 0.5 (gi) 0.7 (c) 0.6 (a) 0.6 (l) 0.6 ( t) 0.6 (ra) 0.7 (nsf) 0.5 (or) 0.5 (m) 0.6 (a) 0.6 (t) 0.6 (i) 0.7 (on) 0.5 ( t) 0.7 (o di) 0.7 (f) 18.5 (fu) 0.5 (se) -6.9 ( ) ] TJ
-0.001 Tc
-0.062 Tw
23.73 29.665 Td
[ (lar) 17.6 (ge B\055cell lymphoma \050D) -0.6 (LBCL\051 involving the s) -0.6 (kin \0504\051\056) -1 ( ) ] TJ
-0.005 Tc
0 -1.143 Td
[ (Cutaneous macroglobulinosis ) 0.5 (has been widely described) -5 ( ) ] TJ
0.008 Tc
0.125 Tw
0 -1.143 Td
[ (\0503\051\056 In c) 0.6 (ont) 0.5 (ra) 0.5 (st) 0.6 (\054 onl) 0.5 (y i) 0.6 (sol) 0.6 (a) 0.5 (t) 0.5 (e) 0.5 (d c) 0.5 (a) 0.5 (se) 0.5 ( re) 0.5 (port) 0.6 (s a) 0.5 (nd sm) 0.5 (a) 0.5 (l) 0.6 (l) 8.1 ( ) ] TJ
0.007 Tc
0 -1.143 Td
[ (series of lymphomatous skin involvement associated) 6.9 ( ) ] TJ
0.002 Tc
0 -1.143 Td
[ (with ) 18.1 (WM have been reported to date \0505\2267\051\056 ) 18.1 (The aim) 2.2 ( ) ] TJ
0 Tc
0.07 Tw
0 -1.143 Td
(of this multicentre retrospective study was to describe ) Tj
-0.063 Tw
0 -1.143 Td
[ (c) 0.7 (l) 0.7 (i) 0.7 (n) 0.5 (i) 0.7 (c) 0.6 (a) 0.7 (l) 0.7 (\054) 0.5 ( b) 0.6 (i) 0.7 (o) 0.5 (l) 0.7 (o) 0.5 (g) 0.5 (i) 0.7 (c) 0.7 (a) 0.7 (l) 0.6 ( a) 0.6 (n) 0.6 (d) 0.5 ( h) 0.5 (i) 0.7 (st) 0.7 (o) 0.5 (l) 0.7 (o) 0.5 (g) 0.5 (i) 0.7 (c) 0.7 (a) 0.6 (l) 0.7 ( f) 0.6 (e) 0.6 (a) 0.7 (t) 0.7 (u) 0.5 (r) 0.5 (e) 0.7 (s\054) 0.5 ( t) 0.7 (h) 0.5 (e) 0.7 (r) 0.5 (a) 0.7 (p) 0.5 (e) 0.7 (u) 0.5 (t) 0.7 (i) 0.7 (c ) ] TJ
-0.007 Tc
-0.062 Tw
0 -1.143 Td
[ (approaches\054 clinical outcome and prognosis) -0.6 ( of cutaneous) -7.1 ( ) ] TJ
0 Tc
-0.018 Tw
0 -1.143 Td
[ (involvement ) -18 (in WM\056) ] TJ
0.9 0.79 0.1 0.01 k
/GS0 gs
/TT1 1 Tf
0 Tw
0 -3.105 Td
[ (MATERIALS) 0.5 ( AND METHODS) ] TJ
0 0 0 1 k
/GS1 gs
/C2_3 1 Tf
9 0 0 9 306.6378 239.3893 Tm
<002c0047004800510057004c00bf004600440057004c0052005100030052004900030046004400560048005600030044005100470003004c00510046004f00580056004c00520051000300460055004c005700480055004c0044> Tj
/TT5 1 Tf
0.031 Tw
9.27 0 0 9 306.6378 224.3893 Tm
[ (The database of the French Cutaneous L) 55.3 (ymphoma Study Group ) ] TJ
0.024 Tw
0 -1.111 Td
(\050GFELC\051 and the participating referring clinicians were queried ) Tj
-0.052 Tw
0 -1.111 Td
(to identify cases \050recruitment method 1\051\056 Furthermore\054 cases with ) Tj
-0.006 Tw
0 -1.111 Td
[ (skin involvement previously included in a series ) 0.5 (of ) 0.5 (patients with ) ] TJ
0.052 Tw
0 -1.111 Td
[ (a ) 18.1 (WM histologically transformed to DLBCL) 37.3 ( were also selected ) ] TJ
0.045 Tw
0 -1.111 Td
[ (\050recruitment method 2\051 \0504\051\056 ) 55.5 (All cases were analysed for the fol) ] TJ
0 Tw
9.27 0 0 9 542.1886 174.3893 Tm
(\055) Tj
0.038 Tw
9.27 0 0 9 306.6378 164.3893 Tm
(lowing inclusion criteria\072 \050) Tj
/TT6 1 Tf
0 Tw
(i) Tj
/C2_2 1 Tf
[ <000c0003> -37.8 <00440003> -37.8 <0047004c0044004a005100520056004c00560003> -37.7 <005200490003> -19.7 <003a00300003> -37.7 <00460052005100bf00550050004800470003> -37.8 <0045005c0003> -37.8 <00440003> ] TJ
/TT5 1 Tf
0.024 Tw
0 -1.111 Td
[ (haematologist\054 ) 0.5 (based ) 0.5 (on ) 0.6 (criteria ) 0.5 (established ) 0.5 (in ) 0.6 (the ) 0.5 (Second ) 0.6 (Inter) ] TJ
0 Tw
9.27 0 0 9 542.1886 154.3893 Tm
(\055) Tj
0.117 Tw
9.27 0 0 9 306.6378 144.3893 Tm
[ (national ) 18.1 (W) 80.2 (orkshop on ) 18.1 (W) 80.2 (aldenstr\366m\222) 55.2 (s macroglobulinaemia \0508\051\073 ) ] TJ
0 Tw
0 -1.111 Td
(\050) Tj
/TT6 1 Tf
(ii) Tj
/TT5 1 Tf
0.042 Tw
(\051 presence at any time of skin lesions diagnosed as cutaneous ) Tj
0.103 Tw
0 -1.111 Td
(location of B\055cell lymphoma\054 whatever the subtype\056 Exclusion ) Tj
-0.061 Tw
0 -1.111 Td
(criteria were\072 \050) Tj
/TT6 1 Tf
0 Tw
(i) Tj
/TT5 1 Tf
-0.061 Tw
(\051 age under 18 years\073 \050) Tj
/TT6 1 Tf
0 Tw
(ii) Tj
/TT5 1 Tf
-0.061 Tw
(\051 non\055lymphomatous cuta) Tj
0 Tw
9.27 0 0 9 542.1887 114.3893 Tm
(\055) Tj
-0.009 Tc
-0.062 Tw
9.27 0 0 9 306.6378 104.3893 Tm
[ (neous lesions including cutaneous macroglobulinosis\054 and variable) -8.9 ( ) ] TJ
/C2_2 1 Tf
0.008 Tc
-0.008 Tw
0 -1.111 Td
[ <004c005100c00044005000500044005700520055005c> 64.8 <000f0003> -125.1 <0051005200510010004f005c00500053004b00520050004400570052005800560003> -125.1 <0047004c00560052005500470048005500560003> -125 <004400490057004800550003> -125 <0048005b00440050004c005100440057004c00520051> 8 <0003> ] TJ
/TT5 1 Tf
0 Tc
-0.01 Tw
0 -1.111 Td
[ (by ) 0.5 (GFELC ) 0.6 (pathologists\073 ) 0.6 (\050) ] TJ
/TT6 1 Tf
0 Tw
(iii) Tj
/TT5 1 Tf
-0.01 Tw
[ (\051 ) 0.5 (absence ) 0.5 (of ) 0.5 (informative ) 0.5 (clinical ) 0.5 (and ) ] TJ
0 Tw
0 -1.111 Td
(pathological data available in medical records\056) Tj
/TT1 1 Tf
16.48 0 0 16 50 714.6696 Tm
[ (Cutaneous Involvement in Waldenstr\366m\222s Macroglobulinaemi) 0.6 (a) ] TJ
/TT0 1 Tf
8.24 0 0 8 50 693.0696 Tm
[ (Sa) 0.8 (r) 17.8 (a) 0.5 (h) ] TJ
/C2_0 1 Tf
[ <0003> 65 <00360037002c00280031> ] TJ
/TT0 1 Tf
4.8039 0 0 4.664 102.0349 695.7336 Tm
(1) Tj
8.24 0 0 8 105.0889 693.0696 Tm
(\054 ) Tj
/C2_0 1 Tf
0.651 0 Td
<00280055004c0046> Tj
[ <0003> 64.9 <0027> 0.5 <003800350032> 24.3 <0037> ] TJ
4.8039 0 0 4.664 157.5701 695.7336 Tm
<0015> Tj
/TT0 1 Tf
8.24 0 0 8 160.6242 693.0696 Tm
(\054 ) Tj
0.651 0 Td
[ (An) 0.6 (ne) ] TJ
/C2_0 1 Tf
[ <0003> 64.9 <0027> 0.5 <00380035002f00240026002b> ] TJ
/TT0 1 Tf
4.8039 0 0 4.664 229.5975 695.7336 Tm
(3) Tj
8.24 0 0 8 232.6515 693.0696 Tm
(\054 ) Tj
/C2_0 1 Tf
0.651 0 Td
<003000440055004c0048> Tj
[ <0003> 64.9 <00250028003c002f> 10.1 <0032> 24.3 <0037> 73 <00100025> 0.5 <002400350035> 9.4 <003c> ] TJ
/TT0 1 Tf
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