Ultrahypofractionation of localized prostate cancer : Statement from the DEGRO working group prostate cancer.

Wolf, Frank; Sedlmayer, Felix; Aebersold, Daniel; Albrecht, Clemens; Böhmer, Dirk; Flentje, Michael; Ganswindt, Ute; Ghadjar, Pirus; Höcht, Stefan; Hölscher, Tobias; Müller, Arndt-Christian; Niehoff, Peter; Pinkawa, Michael; Schmidt-Hegemann, Nina-Sophie; Zamboglou, Constantinos; Zips, Daniel; Wiegel, Thomas (2021). Ultrahypofractionation of localized prostate cancer : Statement from the DEGRO working group prostate cancer. Strahlentherapie und Onkologie, 197(2), pp. 89-96. Springer 10.1007/s00066-020-01723-8

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Due to its low fractionation sensitivity, also known as "alpha/beta ratio," in relation to its surrounding organs at risk, prostate cancer is predestined for hypofractionated radiation schedules assuming an increased therapeutic ratio compared to normofractionated regimens. While moderate hypofractionation (2.2-4 Gy) has been proven to be non-inferior to normal fractionation in several large randomized trials for localized prostate cancer, level I evidence for ultrahypofractionation (>4 Gy) was lacking until recently. An accumulating body of non-randomized evidence has recently been strengthened by the publication of two randomized studies comparing ultrahypofractionation with a normofractionated schedule, i.e., the Scandinavian HYPO-RT trial by Widmark et al. and the first toxicity results of the PACE‑B trial. In this review, we aim to give a brief overview of the current evidence of ultrahypofractionation, make an overall assessment of the level of evidence, and provide recommendations and requirements that should be followed before introducing ultrahypofractionation into routine clinical use.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Aebersold, Daniel and Ghadjar, Pirus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-099X

Publisher:

Springer

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

05 Jan 2021 16:33

Last Modified:

29 Jan 2021 01:33

Publisher DOI:

10.1007/s00066-020-01723-8

PubMed ID:

33301049

Uncontrolled Keywords:

Extreme hypofractionation Hypofractionation Radiotherapy SABR SBRT

BORIS DOI:

10.48350/149639

URI:

https://boris.unibe.ch/id/eprint/149639

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