Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA.

Brendel, Matthias; Catak, Cihan; Beyer, Leonie; Linn, Jennifer; Wahl, Hannes; Janowitz, Daniel; Rominger, Axel; Patt, Marianne; Barthel, Henryk; Sabri, Osama; Bartenstein, Peter; Wollenweber, Frank Arne (2020). Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA. Case reports in neurology, 12(2), pp. 232-237. Karger 10.1159/000506765

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Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified Boston criteria and underwent longitudinal magnetic resonance imaging, amyloid positron emission tomography (PET), and additional tau PET imaging. Amyloid deposition presented predominantly in the contralateral hemisphere not affected by cSS. In contrast, tau deposition was predominantly overlapping with brain regions affected by cSS. Amyloid deposition was not different in the vicinity of cSS whereas tau depositions were elevated in the vicinity of CSS-affected regions compared to non-cSS-affected brain regions. This case of probable CAA suggests that cSS may be associated with a locally elevated tau pathology but not with increased fibrillary amyloid deposition.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-680X

Publisher:

Karger

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

05 Jan 2021 17:22

Last Modified:

05 Jan 2021 17:22

Publisher DOI:

10.1159/000506765

PubMed ID:

32774280

Uncontrolled Keywords:

Amyloid imaging Cerebral amyloid angiopathy Cortical superficial siderosis Tau imaging

BORIS DOI:

10.7892/boris.149665

URI:

https://boris.unibe.ch/id/eprint/149665

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