Riedel, René; Addo, Richard; Ferreira-Gomes, Marta; Heinz, Gitta Anne; Heinrich, Frederik; Kummer, Jannis; Greiff, Victor; Schulz, Daniel; Klaeden, Cora; Cornelis, Rebecca; Menzel, Ulrike; Kröger, Stefan; Stervbo, Ulrik; Köhler, Ralf; Haftmann, Claudia; Kühnel, Silvia; Lehmann, Katrin; Maschmeyer, Patrick; McGrath, Mairi; Naundorf, Sandra; ... (2020). Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow. Nature Communications, 11(1), p. 2570. Springer Nature 10.1038/s41467-020-16464-6
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At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie |
UniBE Contributor: |
Zimmermann, Jakob |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2041-1723 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
22 Dec 2020 17:02 |
Last Modified: |
05 Dec 2022 15:43 |
Publisher DOI: |
10.1038/s41467-020-16464-6 |
PubMed ID: |
32444631 |
BORIS DOI: |
10.7892/boris.149740 |
URI: |
https://boris.unibe.ch/id/eprint/149740 |
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