Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins.

Gigon, Lea; Yousefi, Shida; Karaulov, Alexander; Simon, Hans-Uwe (2021). Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins. Allergology international, 70(1), pp. 30-38. Elsevier 10.1016/j.alit.2020.11.003

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Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Gigon, Lea; Yousefi, Shida and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1440-1592

Publisher:

Elsevier

Language:

English

Submitter:

Celine Joray

Date Deposited:

12 Jan 2021 17:05

Last Modified:

31 Mar 2021 17:16

Publisher DOI:

10.1016/j.alit.2020.11.003

PubMed ID:

33277190

Uncontrolled Keywords:

Cytotoxicity Eosinophil Granule protein Innate immunity Neutrophil

BORIS DOI:

10.48350/149753

URI:

https://boris.unibe.ch/id/eprint/149753

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