Temperatures, diagnostics and treatment in pediatric cancer patients with fever in neutropenia, NCT01683370.

Brack, Eva; Wagner, Stéphanie; Stutz-Grunder, Eveline; Agyeman, Philipp K.A.; Ammann, Roland A. (2020). Temperatures, diagnostics and treatment in pediatric cancer patients with fever in neutropenia, NCT01683370. Scientific data, 7(1), p. 156. Nature Publishing Group 10.1038/s41597-020-0504-9

[img]
Preview
Text
BrackWagner_SciDat2020.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (945kB) | Preview

In pediatric oncology, there is no evidence-based definition of the temperature limit defining fever (TLDF), which itself is essential for the definition of fever in chemotherapy-induced severe neutropenia (FN). Lowering the TLDF can increase the number of FN episodes diagnosed. This prospective, single center observational study collected data on all temperature measurements, complete blood counts (CBCs), and measures of diagnostics and therapy performed at and after FN diagnosis in pediatric oncology patients using a high standard TLDF (39 °C ear temperature). In 45 FN episodes in 20 patients, 3391 temperature measurements and 318 CBCs, plus information on antibiotics, anti-fungal therapy, antipyretics, blood cultures taken and on discharge were collected. These data can mainly be used to study the influence of virtually lowering the TLDF on diagnostic measures, treatment and length of hospitalization in pediatric FN, which in turn are directly related to costs of FN therapy, and quality of life. This approach can be expanded to include as well different definitions of neutropenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

UniBE Contributor:

Brack, Eva Katharina; Wagner, Stéphanie; Stutz-Grunder, Eveline; Agyeman, Philipp Kwame Abayie and Ammann, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2052-4463

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Philipp Agyeman

Date Deposited:

11 Jan 2021 12:07

Last Modified:

13 Mar 2021 20:28

Publisher DOI:

10.1038/s41597-020-0504-9

PubMed ID:

32457478

BORIS DOI:

10.48350/149765

URI:

https://boris.unibe.ch/id/eprint/149765

Actions (login required)

Edit item Edit item
Provide Feedback