Does the Animal Model Influence in Vertical Alveolar Distraction? A Systematic Review of the Literature.

García-González, Mario; Muñoz, Fernando; González-Cantalapiedra, Antonio; López-Peña, Mónica; Saulacic, Nikola (2020). Does the Animal Model Influence in Vertical Alveolar Distraction? A Systematic Review of the Literature. Animals, 10(12) MDPI 10.3390/ani10122347

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This study is aimed at synthesizing all available evidence on vertical alveolar osteogenesis distraction (VAOD) in animal trials to determine whether the animal model used and its handling influence or not, and find which is the most appropriate animal model for this specific technique. This systematic review has been carried out following the PRISMA statements. Bibliographic sources have been consulted manually by two reviewers. Risk of bias was assessed using a version of the Newcastle-Ottawa-Scale (NOS). The selection criteria established by expert researchers were applied in order to decide which studies should be included in the review. Twenty-six studies met the inclusion criteria and were included in the review. Twenty-four of them had a high quality (score between 7 and 9), two medium quality (score between 4 and 6), and none low quality (score between 1 and 3). The highest possible score was 9 (using the NOS). Six studies complied with all NOS criteria. The animal model has been seen to influence the results, leading to failure in some cases. The most used animal model on VAOD, with fewer complications, was the Mongrel dog. The use of the pig and minipig is not recommended, due to the difficulties in handling and complications encountered.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Saulacic, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2076-2615

Publisher:

MDPI

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

28 Dec 2020 18:04

Last Modified:

28 Dec 2020 18:13

Publisher DOI:

10.3390/ani10122347

PubMed ID:

33317062

Uncontrolled Keywords:

VAOD alveolar ridge augmentation animal experimentation animal model biomaterials distraction osteogenesis systematic review

BORIS DOI:

10.48350/149766

URI:

https://boris.unibe.ch/id/eprint/149766

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