Management of children with fever and neutropenia: results of a survey in 51 pediatric cancer centers in Germany, Austria, and Switzerland.

Scheler, Max; Lehrnbecher, Thomas; Groll, Andreas H; Volland, Ruth; Laws, Hans-Jürgen; Ammann, Roland A.; Agyeman, Philipp; Attarbaschi, Andishe; Lux, Margaux; Simon, Arne (2020). Management of children with fever and neutropenia: results of a survey in 51 pediatric cancer centers in Germany, Austria, and Switzerland. Infection, 48(4), pp. 607-618. 10.1007/s15010-020-01462-z

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PURPOSE

Investigation of the current practice of diagnostics and treatment in pediatric cancer patients with febrile neutropenia.

METHODS

On behalf of the German Society for Pediatric Oncology and Hematology and the German Society for Pediatric Infectious Diseases, an Internet-based survey was conducted in 2016 concerning the management of febrile neutropenia in pediatric oncology centers (POC). This survey accompanied the release of the corresponding German guideline to document current practice before its implementation in clinical practice.

RESULTS

In total, 51 POCs participated (response rate 73%; 43 from Germany, and 4 each from Austria and Switzerland). Identified targets for antimicrobial stewardship concerned blood culture diagnostics, documentation of the time to antibiotics, the use of empirical combination therapy, drug monitoring of aminoglycosides, the time to escalation in patients with persisting fever, minimal duration of IV treatment, sequential oral treatment in patients with persisting neutropenia, indication for and choice of empirical antifungal treatment, and the local availability of a pediatric infectious diseases consultation service.

CONCLUSION

This survey provides useful information for local antibiotic stewardship teams to improve the current practice referring to the corresponding national and international guidelines.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

UniBE Contributor:

Ammann, Roland and Agyeman, Philipp Kwame Abayie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-0973

Language:

English

Submitter:

Philipp Agyeman

Date Deposited:

11 Jan 2021 14:10

Last Modified:

17 Mar 2021 06:38

Publisher DOI:

10.1007/s15010-020-01462-z

PubMed ID:

32524514

Uncontrolled Keywords:

Antimicrobial treatment Febrile neutropenia Pediatric cancer patients Survey

BORIS DOI:

10.48350/149768

URI:

https://boris.unibe.ch/id/eprint/149768

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