Does nutrition for cancer patients feed the tumour? A clinical perspective.

Bozzetti, F; Stanga, Zeno (2020). Does nutrition for cancer patients feed the tumour? A clinical perspective. Critical reviews in oncology, hematology, 153(103061), p. 103061. Elsevier 10.1016/j.critrevonc.2020.103061

Text 1-s2.0-S1040842820301979-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB)

This review aims to answer to two basic questions: a) Which substrates does a tumour utilize and is there a regimen that might potentially favour the host over the tumour? and b) Does nutritional intervention disproportionally affect tumour growth? Literature to date focuses on humans; although some references to molecular mechanisms regulating cancer cells metabolism derive from studies on experimental tumours and cell biology. Literature shows that some tumours, especially those of the brain and head/neck and lung, are glucose-dependent, and patients with these tumours could benefit from a normocaloric ketogenic diet provided these tumours exhibit high fluorodeoxyglucose (18F-FDG) captation. A high fat-protein, low carbohydrate diet appears to better fulfil the nutritional requirements of the cancer patient. Current evidence shows no improvement in tumoral response after restricting patients' caloric intake; whereas malnutrition is acknowledged as an important negative predictive and prognostic factor in all cancer patients.

Interest & Impact

Downloads

1 since deposited on 13 Jan 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item