Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients.

He, Shenghong; Mostofi, Abteen; Syed, Emilie; Torrecillos, Flavie; Tinkhauser, Gerd; Fischer, Petra; Pogosyan, Alek; Hasegawa, Harutomo; Li, Yuanqing; Ashkan, Keyoumars; Pereira, Erlick; Brown, Peter; Tan, Huiling (2020). Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients. eLife, 9(e60979) eLife Sciences Publications 10.7554/eLife.60979

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Previous studies have explored neurofeedback training for Parkinsonian patients to suppress beta oscillations in the subthalamic nucleus (STN). However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm targeting STN beta bursts and investigated whether neurofeedback training could improve motor initiation in Parkinson's disease compared to passive observation. Our task additionally allowed us to test which endogenous changes in oscillatory STN activities are associated with trial-to-trial motor performance. Neurofeedback training reduced beta synchrony and increased gamma activity within the STN, and reduced beta band coupling between the STN and motor cortex. These changes were accompanied by reduced reaction times in subsequently cued movements. However, in Parkinsonian patients with pre-existing symptoms of tremor, successful volitional beta suppression was associated with an amplification of tremor which correlated with theta band activity in STN local field potentials, suggesting an additional cross-frequency interaction between STN beta and theta activities.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2050-084X

Publisher:

eLife Sciences Publications

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

11 Jan 2021 08:31

Last Modified:

11 Jan 2021 08:31

Publisher DOI:

10.7554/eLife.60979

PubMed ID:

33205752

Uncontrolled Keywords:

beta burst beta oscillations human neurofeedback neuroscience parkinson's disease parkinsonian tremor

BORIS DOI:

10.48350/149888

URI:

https://boris.unibe.ch/id/eprint/149888

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