Water and lipid suppression techniques for advanced 1 H MRS and MRSI of the human brain: Experts' consensus recommendations.

Tkáč, Ivan; Deelchand, Dinesh; Dreher, Wolfgang; Hetherington, Hoby; Kreis, Roland; Kumaragamage, Chathura; Považan, Michal; Spielman, Daniel M; Strasser, Bernhard; de Graaf, Robin A (2021). Water and lipid suppression techniques for advanced 1 H MRS and MRSI of the human brain: Experts' consensus recommendations. NMR in biomedicine, 34(5), e4459. Wiley 10.1002/nbm.4459

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The neurochemical information provided by proton magnetic resonance spectroscopy (MRS) or MR spectroscopic imaging (MRSI) can be severely compromised if strong signals originating from brain water and extracranial lipids are not properly suppressed. The authors of this paper present an overview of advanced water/lipid-suppression techniques and describe their advantages and disadvantages. Moreover, they provide recommendations for choosing the most appropriate techniques for proper use. Methods of water signal handling are primarily focused on the VAPOR technique and on MRS without water suppression (metabolite cycling). The section on lipid-suppression methods in MRSI is divided into three parts. First, lipid-suppression techniques that can be implemented on most clinical MR scanners (volume preselection, outer-volume suppression, selective lipid suppression) are described. Second, lipid-suppression techniques utilizing the combination of k-space filtering, high spatial resolutions and lipid regularization are presented. Finally, three promising new lipid-suppression techniques, which require special hardware (a multi-channel transmit system for dynamic B1+ shimming, a dedicated second-order gradient system or an outer volume crusher coil) are introduced.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

UniBE Contributor:

Kreis, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1099-1492

Publisher:

Wiley

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

06 Jan 2021 15:57

Last Modified:

21 Apr 2021 01:32

Publisher DOI:

10.1002/nbm.4459

PubMed ID:

33327042

Uncontrolled Keywords:

ECLIPSE L-regularization VAPOR crusher coils dynamic B1 shimming high spatial resolution inversion recovery metabolite cycling

BORIS DOI:

10.48350/149953

URI:

https://boris.unibe.ch/id/eprint/149953

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