Meta-analysis as a system of springs.

Papakonstantinou, Theodoros; Nikolakopoulou, Adriani; Egger, Matthias; Salanti, Georgia (2021). Meta-analysis as a system of springs. Research Synthesis Methods, 12(1), pp. 20-28. Wiley 10.1002/jrsm.1470

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Meta-analysis results are usually presented in forest plots, which show the individual study results and the summary effect along with their confidence intervals. In this paper, we propose a system of linear springs as a mechanical analogue of metaanalysis that enables visualisation and enhances intuition. The length of a spring corresponds to a study treatment effect and the stiffness of the spring corresponds to its inverse variance. To synthesise study springs we use two main operations: connection in parallel and connection in series. We show the equivalence between meta-analysis and linear springs for fixed effect and random effects pairwise metaanalysis and we also derive indirect treatment effects. We use examples to illustrate the different meta-analytical schemes using the corresponding system of springs. The proposed visualization tool can serve as an educational plot, especially useful for researchers with no statistical background. The analogy between meta-analysis and springs facilitates intuition for notions such as heterogeneity and the differences between fixed and random effects meta-analysis. This article is protected by copyright. All rights reserved.

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