Hemolytic-uremic syndrome in Switzerland: a nationwide surveillance 1997-2003

Schifferli, Alexandra; von Vigier, Rodo O; Fontana, Matteo; Spartà, Giuseppina; Schmid, Hans; Bianchetti, Mario G; Rudin, Christoph (2010). Hemolytic-uremic syndrome in Switzerland: a nationwide surveillance 1997-2003. European journal of pediatrics, 169(5), pp. 591-8. Berlin: Springer 10.1007/s00431-009-1079-9

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Hemolytic-uremic syndrome (HUS) is a leading cause of acute renal failure in childhood. In its typical presentation, it is preceded by an episode of diarrhea mostly due to Shiga-toxin-producing Escherichia coli. There is important geographical variation of many aspects of this syndrome. Nationwide data on childhood HUS in Switzerland have not been available so far. In a prospective national study through the Swiss Pediatric Surveillance Unit 114 cases (median age 21 months, 50% boys) were reported between April 1997 and March 2003 by 38 pediatric units (annual incidence 1.42 per 10(5) children < or =16 years). Shiga-toxin-producing E. coli were isolated in 32 (60%) of tested stool samples, serotype O157:H7 in eight. Sixteen children presented with only minimal renal involvement, including three with underlying urinary tract infection. Six patients presented with atypical hemolytic-uremic syndrome, and six with HUS due to invasive Streptococcus pneumoniae infection. Mortality was 5.3%, including two out of six children with S. pneumoniae infection. The severity of thrombocytopenia and the presence of central nervous system involvement significantly correlated with mortality. In conclusion, childhood HUS is not rare in Switzerland. Contrasting other countries, E. coli O157:H7 play only a minor role in the etiology. Incomplete manifestation is not uncommon.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Bianchetti, Mario Giovanni

ISSN:

0340-6199

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

17 Mar 2015 19:07

Publisher DOI:

10.1007/s00431-009-1079-9

PubMed ID:

19830454

Web of Science ID:

000275421100013

URI:

https://boris.unibe.ch/id/eprint/150 (FactScience: 196565)

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